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青岛地区汉族人群乙醛脱氢酶基因多态性与高密度脂蛋白胆固醇的相关性

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摘要 目的探讨青岛地区汉族人群ALDH2(Glu487Lys)基因多态性与高密度脂蛋白胆固醇(HDL-C)的相关性。方法采用基因芯片技术测定618例60~90〔平均(72±13.9)〕岁高脂血症患者的ALDH2(Glu487Lys)基因多态性,按基因型分为野生型GG组(393例)和突变型GA/AA组(225例),比较两组血浆HDL-C水平,应用多分类、多因素Logistic回归分析其基因多态性对HDL-C的影响。结果 ALDH2野生组与突变组的HDL-C含量有统计学意义(P=0.021)。多元线性回归分析显示性别、吸烟史、糖尿病史、ALDH2基因型是HDL-C的影响因素(标准回归系数分别为-0.084,0.099,0.158,0.216;P<0.05);协方差分析显示罹患糖尿病、吸烟、性别与基因型无交互作用(P值均>0.05),且共同影响HDL-C含量(P<0.05)。结论 ALDH2(Glu487Lys)基因多态性与HDL-C存在相关性。
作者 赵新秀 王仁萍 胡松 贾韵平 毛拥军
机构地区 浙江大学附属第一医院 青岛大学医学院老年医学教研室
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第24期7170-7172,共3页 Chinese Journal of Gerontology
关键词 ALDH2(Glu487Lys) 高密度脂蛋白胆固醇 基因多态性
分类号 R589.2 [医药卫生—内分泌]
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中国老年学杂志
2015年 第24期

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