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E-cadherin和VEGF在老年骨巨细胞瘤中的表达及意义 被引量:2

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摘要 目的探讨上皮型钙黏附蛋白(E-cadherin)和血管内皮生长因子(VEGF)在老年骨巨细胞瘤(GCTB)中的表达及其意义。方法随机选取GCTB老年(年龄≥60岁)患者40例,采用免疫组织化学法检测病理标本中E-cadherin和VEGF的表达情况,并分析二者与患者临床资料的关系。结果 E-cadherin在Ⅰ级GCTB中的阳性表达率要显著高于Ⅱ级和Ⅲ级(P<0.05),VEGF在Ⅰ级GCTB中的阳性表达率显著低于Ⅱ级和Ⅲ级(P<0.05);E-cadherin和VEGF的表达与患者性别和年龄无关(P>0.05),而与组织学分级、肿瘤复发和转移情况有关(P<0.05);E-cadherin与VEGF在GCTB组织中的表达呈负相关(r=-0.793,P<0.05)。结论 E-cadherin和VEGF在GCTB中的表达会发生变化,这与GCTB的转移密切相关,有助于对患者的预后进行判断。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第19期5534-5536,共3页 Chinese Journal of Gerontology
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