摘要
目的:检测桥本甲状腺炎(HT)患者血浆IL-23和IL-17的水平,探讨其临床意义。方法:采用酶联免疫吸附试验(ELASA)检测61例HT患者和37名健康对照者血浆IL-23和IL-17水平并分析二者相关性,同时分析IL-23与自身抗体的相关性。结果:HT患者血浆IL-23和IL-17水平明显高于健康对照者(P<0.01),两者存在显著正相关(r=0.465 9,P=0.000 2);甲状腺功能减低的HT患者血浆中IL-23水平与其血清甲状腺球蛋白抗体(TGAb,r=0.392 9,P=0.012 1)、甲状腺过氧化物酶抗体(TPOAb,r=0.334 7,P=0.034 8)水平存在正相关,而甲状腺功能正常的HT患者血浆中IL-23水平与其血清TGAb(r=0.155 4,P=0.501 1)、TPOAb(r=-0.194 9,P=0.395 3)水平无明显相关性。结论:IL-23在桥本甲状腺炎发病中起重要作用。
Objective: To determine the levels of plasma interleukin-23( IL-23) and interleukin-17( IL-17),and analyze the clinical significance of them in patients with Hashimoto’s thyroiditis( HT). Methods:Enzyme linked immunosorbent assay( ELISA) was used to analyze the concentration of plasma IL-23 and IL-17 in 61 HT patients and 37 healthy controls. Results: The concentration of plasma IL-23 and IL-17 was significantly elevated in the HT patients than the controls( P < 0. 01). A positive correlation was observed between the level of IL-23 and IL-17. The level of plasma IL-23 in hypothyroid patients with HT showed positive correlations with the level of serum TGAb or TPOAb,but the correlation between the level of plasma IL-23 in euthyroid patients and the level of serum TGAb or TPOAb were not found. Conclusion: IL-23 may play an important role in the pathogenesis of HT.
出处
《江苏大学学报（医学版）》
CAS
2015年第4期331-334,共4页
Journal of Jiangsu University：Medicine Edition
基金
江苏省卫生厅医学科研资助项目(H200952)
镇江市社会发展资助项目(SH2013040)
