摘要
通过对新合成的噻唑烷酸衍生物Ⅳ-苄氧羰基-L-噻唑烷-4-羧酰-L-苯丙氨酸、2-苯基-L-噻唑烷-4-羧酸、2,2-二甲基-L-噻唑烷-4-羧酸等诱导HeLa细胞逆向转化的初步实验研究,提出噻唑烷酸的抗肿瘤活性应考虑其分子释放醛的影响。
Timonacic (L-thiazolidine-4-carboxylic acid) is a proposed anti- tumor agent. Its derivatives and analogues, (N-carbobenzoxy-L-thiazolidine-4- carboxyl)-L-phenylalanine (1), 2-phenyl-L-thiazolidine-4-carboxylic acid (2) and 2,2-dimethyl-L-thiazolidine-4-carboxylic acid (3) were synthesized and investiga- ted for their, ability to induce reverse transformation of HeLa cells in vitro. Experimental results indicatod that 1 and 2 showed some effects but 3 no effect. Winferred that non-cytotoxic antitumor activity of timonacic might relate to the release of formaldehyde.
出处
《医药工业》
CAS
1987年第8期351-356,共6页
