摘要
目的应用磁共振灌注加权成像研究高血压脑出血急性期和亚急性期血肿周围组织脑血流量的改变。方法连续入组2011年10月至2013年9月期间在南通大学附属医院神经内科住院治疗的高血压脑出血(hypertensive intracerebral hemorrhage,HICH)患者24例。所有患者于发病第3天、14天进行MRI检查,应用灌注加权成像(perfusion weighted imaging,PWI)测定并计算血肿周围1 cm区域、血肿周围损伤区域和血肿远隔区域的相对脑血流量(relative cerebral blood flow,r CBF)。结果发病第3天、14天时,血肿周围1 cm区域、血肿周围损伤区域的r CBF均显著低于血肿远隔区域。与发病第3天相比,发病第14天时血肿周围1 cm区域、血肿周围损伤区域的r CBF均显著下降。结论高血压脑出血的急性期和亚急性期,血肿周围组织存在明显的低灌注,亚急性期比急性期更严重。磁共振灌注加权成像能清晰显示血肿周围组织的脑血流量改变,有一定的临床实用价值。
Objective To study alterations of cerebral blood flow in perihematomal tissue in acute and subacute hypertensive intracerebral hemorrhage with MRI perfusion weighted imaging.Methods 24 consecutive patients with hypertensive intracerebral hemorrhage (HICH) admitted to the department of neurology of the afifliated hospital of Nantong university from October 2011 to September 2013 were recruited in the study. All patients underwent magnetic resonance imaging at days 3 and 14 after symptom onset. The relative cerebral blood lfow (rCBF) was measured and calculated using perfusion weighted imaging (PWI) in the 1 cm-wide area around the hematoma, as well as in the damaged area around the hematoma and the ipsilateral remote area.Results The values of rCBF in the 1 cm-wide area around the hematoma and in the damaged area around the hematoma were signiifcantly lower than in the ipsilateral remote area at days 3 and 14 after symptom onset. Compared with day 3 after symptom onset, the values of rCBF in the 1 cm-wide area around the hematoma and in the damaged area around the hematoma were signiifcantly decreased at day 14 after symptom onset.Conclusions There exits pronounced hypoperfusion in the tissue around the hematoma during the phases of acute and subacute hypertensive intracerebral hemorrhage. MRI perfusion weighted imaging may contribute to display the alteration of cerebral blood lfow of perihematomal tissue, and be with certain clinical applicatin value.
出处
《中华脑血管病杂志(电子版)》
2014年第2期4-8,共5页
Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
关键词
脑出血
血肿周围组织
磁共振
灌注加权成像
Intracerebral hemorrhage
Perihematomal tissue
MRI
Perfusion weighted imaging