摘要
胃癌是世界上因癌症死亡的主要原因之一,尽早发现肿瘤是改善胃癌预后的关键。因此,寻找胃癌相关肿瘤标志物就成了当前研究领域的热点问题。蛋白质组学的广泛应用得益于其不断革新的研究技术,使大量的胃癌标本得以被筛选,比如细胞、组织、血液和幽门螺旋杆菌感染的标本等,从而鉴别出具有相对特异性及灵敏度的新型潜在肿瘤标志物。我们对既往蛋白质组学在胃癌不同标本中的研究进行了回顾,讨论了这些可能作为胃癌潜在标志物的蛋白质特征及作用,并分析了目前蛋白质组学在胃癌研究方面存在的一些问题及发展前景。
Gastric cancer is one of the leading causes of cancer death in the world,early detection is the key to improve the prognosis of gastric cancer.Therefore,finding tumor markers related to gastric cancer has become a hot issue in the current research field.The widespread use of proteomics has benefited from its revolutionary research techniques,allowing a large number of specimens to be screened,such as cancer cell lines,cancer tissues,blood of cancer patients and specimens infected with Helicobacter pylori.Because of this,we can identify novel potential tumor markers with relatively high specificity and sensitivity.In this article we review the research progress in proteomics of gastric cancer by using different specimens,discuss the characteristics and functions of potential marker proteins of gastric cancer,and analyze some existing problems and prospects of proteomics in gastric cancer research.
作者
李滕
王晓龙
张成武
LI Teng;WANG Xiao-long;ZHANG Cheng-wu(Affiliated Hospital of Qinghai University,Xining 810001,China)
出处
《中国肿瘤》
CAS
CSCD
北大核心
2019年第4期295-300,共6页
China Cancer
基金
青海省科学技术厅基金项目(2018-SF-113)
关键词
蛋白质组学
胃癌标本
肿瘤标志物
蛋白质组学技术
proteomics
specimens of gastric cancer
tumor markers
proteomics research techniques
