摘要
目的研究并分析曲美他嗪联合他汀类药物治疗心绞痛的临床效果。方法选择在2016年9月至2018年10月本院收治的193例心绞痛患者作为研究对象,随机分为A组(97例)和B组(96例),所有患者均实施基础治疗,A组患者加用曲美他嗪治疗,B组患者联合使用曲美他嗪和他汀类药物进行治疗,对两组患者左心室收缩末期内径(LVESD)mm、左心室射血分数(LVEF)%、心脏指数(CO)(L/min)、治疗总有效率以及生化指标进行对比和分析。结果治疗之前两组患者左心室收缩末期内径(LVESD)mm、左心室射血分数(LVEF)%、心脏指数(CO)(L/min)均无明显差异,P>0.05;治疗之后B组患者LEVSD(31.2±4.1)mm、LVEF(59.3±6.3)%、CO(5.9±0.8)L/min改善情况均显著优于A组,P<0.05;B组患者的治疗总有效率96.87%(93/96)显著优于A组,P<0.05;治疗之后B组患者HDL-C、LDL-C、TG、TC等生化指标均显著优于A组患者,P<0.05。结论心绞痛患者采用曲美他嗪联合他汀类药物进行治疗,可以显著改善心脏功能,提高治疗效果,值得在临床中应用。
Objective To study and analyze clinical effect of trimetazidine combined with statins in treatment of angina pectoris.Methods Choose 193 cases angina pectoris patients admitted to our hospital from September 2016 to October 2018 as study objects,divide them into group A(97 cases)and group B(96 cases)randomly.All patients were treated with basic therapy,group A was treated with trimetazidine on the basis,and group B with trimetazidine and statins.Compare and analyze left ventricular end systolic diameter(LVESD)mm,left ventricular ejection fraction(LVEF)%,cardiac index(CO)(L/min),total effective rate and biochemical indexes of two groups.Results Before treatment,left ventricular end systolic diameter(LVESD)mm,left ventricular ejection fraction(LVEF)and cardiac index(CO)(L/min)showed no significant differences between two groups,(P>0.05);after treatment,improvement of LEVSD(31.2±4.1)mm,LVEF(59.3±6.3)%and CO(5.9±0.8)L/min in group B was significantly better than group A,(P<0.05);total effective rate of group B was 96.87%(93/96).)After treatment,biochemical indexes of HDL-C,LDL-C,TG and TC in group B were significantly better than group A,(P<0.05).Conclusion Trimetazidine combined with statins can improve cardiac function and curative effect of angina pectoris patients significantly,which is worthy of clinical application.
作者
许海峰
XU Hai-feng(Xiajin County People's Hospital,,Dezhou,Shandong,253200)
出处
《智慧健康》
2019年第12期156-158,共3页
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