摘要
目的探讨参苓白术颗粒对小儿反复呼吸道感染患者免疫功能的影响。方法随机筛选出我院在2015年9月至2016年8月期间收治的58例小儿反复呼吸道感染患儿作为研究对象,采用奇偶分组法分为对照组和观察组,每组29例。对照组患儿单独采用左旋咪唑进行治疗,在此基础上,观察组患儿加用参苓白术颗粒进行治疗。对比两组患儿临床治疗效果和发热、咳嗽、扁桃体肿大、肺部啰音等临床症状消失时间;并在治疗前后分别对两组患儿免疫球蛋白相关指标(IgG、IgA、IgM)和T细胞亚群相关指标(CD3、CD4、CD8、CD4/CD8)进行检测并对比。结果观察组患儿临床治疗总有效率为96.55%,对照组为86.21%,差异有统计学意义(P<0.05)。观察组患儿发热、咳嗽、扁桃体肿大以及肺部啰音等临床症状消失时间均较短,与对照组患儿相比,差异显著(P<0.05)。治疗前两组患儿Ig G、Ig A、Ig M和CD3、CD4、CD8、CD4/CD8水平比较均无明显差异,不具有统计学意义(P>0.05);治疗后观察组患儿IgG、IgA、IgM和CD3、CD4、CD4/CD8水平均比治疗前高,差异显著(P<0.05),治疗前后观察组患儿CD8水平比较,差异无统计学意义(P>0.05);治疗后对照组患儿CD3、CD4、CD8、CD4/CD8水平与治疗前比较均无明显差异(P>0.05);治疗后观察组患儿IgG、IgA、IgM和CD3、CD4、CD4/CD8水平明显高于对照组(P<0.05),但两组患儿CD8水平比较无明显差异(P>0.05)。结论参苓白术颗粒治疗小儿反复呼吸道感染临床效果较好,可在短时间内改善患儿临床症状,且有利于提高患儿免疫功能,值得在临床医学中推广与应用。
Objective To investigate the effect of Shenlingbaizhu Granule on immune function in patients with recurrent respiratory tract infection. Methods Randomly selected 58 cases of children in our hospital during the period from September 2015 to August 2016 were in children with recurrent respiratory tract infection as the research object, divided into the observation group and the control group by parity grouping method, 29 cases in each group. The control group were treated with levamisole imidazole treatment alone, on the basis of this, the patients in the observation group was treated with Shenling Baizhu granules. Comparison of two groups of clinical curative effect and fever, cough, tonsil enlargement, pulmonary rales and other symptoms disappeared time; and respectively before and after treatment in the two groups of children with immunoglobulin related indicators(Ig G, Ig A, Ig M) and T cell subsets(CD3, CD4, correlation index CD8, CD4/CD8) were detected and compared.Results The clinical observation of treatment group in the total efficiency was 96.55%, 86.21% in the control group, the difference was statistically significant(P<0.05). The observation group of children with fever, cough, tonsil enlargement and pulmonary rales and other symptoms disappeared time were shorter, compared with the control group, the difference was significant(P<0.05).Before treatment, two groups of Ig G, Ig A, Ig M and CD3, CD4, CD8, CD4/CD8 levels were no significant difference was not statistically significant(P>0.05); the observation group with Ig G, Ig A after treatment, Ig M and CD3, CD4, CD4/CD8 levels were higher than before treatment, the difference was significant(P<0.05), before and after the treatment, the observation group with the level of CD8, there was no statistically significant difference(P>0.05);After treatment, the control group were CD3, CD4, CD8, CD4/CD8 levels before treatment had no significant difference(P>0.05); the observation group with Ig G, Ig A after treatment, Ig M and CD3, CD4, CD4/CD8 was significan
出处
《智慧健康》
2017年第5期194-196,共3页
Smart Healthcare
关键词
参苓白术颗粒
小儿
呼吸道感染
免疫功能
Shenlingbaizhu granule
Children
Respiratory tract infection
Immune function
