摘要
目的探讨阿尔茨海默病(Alzheimer disease,AD)与载脂蛋白E(ApoE)基因多态性的关系。方法采用PCR-RFLP方法,选取2011年1月到2012年11月我院60例AD患者,将60例AD患者分成36例晚发型AD(LOAD)、24例早发型AD(EOAD),作为观察组,另取同期的60例对照组进行ApoE基因型测定,对AD患者的ApoE基因多态性进行相关分析。结果两组人群ε3/ε3基因型比例最大,未发现ε2/ε2基因型。APOEε4携带者的频率在LOAD组中是52.8%(19/36),对照组15.0%(9/60),其差别有显著性(V2=36.2,P【0.05);APOEε4携带者的频率与EOAD呈显著性相关(V2=6.11,P【0.05)。结论 ApoEε4等位基因与LOAD、EOAD呈显著性相关,是AD的危险因素之一。
Objective To study the Alzheimer’s disease(Alzheimer disease,AD) and apolipoprotein E(ApoE) gene polymorphisms of the relationship.Methods Using PCR-RFL P method,the selection of January 2011 to November 2012 sixty cases of our patients with AD,sixty cases of AD patients into 36 patients with late onset AD(LOAD),24 cases of early hairstyle AD(EOAD),as the observation group and the other take the sixty cases of control group ApoE gene type determination,in patients with AD to the ApoE gene polymorphism in correlation analysis.Results Two groups of people ε3/ε3 genotype proportion is the largest,did not find ε2/ε2 genotype.APOE epsilon4 carrier frequency in the LOAD group was 52.8%(19/36),control group 15.0%(9/60),the difference was obvious(V2=36.2,P<0.05) ;APOEE4 carrier frequency and EOAD is significantly related to the(V2 = 6.11,P<0.05).Conclusion ApoE epsilon4 alleles and LOAD,EOAD is significantly related to the,is one of the risk factors of the AD.
出处
《中国保健营养（下半月）》
2013年第4期523-524,共2页
China Health Care & Nutrition
