摘要
目的:近年来,多项研究探讨了人类白细胞抗原HLA-A*31:01等位基因与抗癫痫药拉莫三嗪(LTG)所致皮肤型药物不良反应(cADRs)的关联性,但目前尚无确定的结论。因此,本研究拟通过一项Meta分析来系统评价HLA-A*31:01等位基因与拉莫三嗪所致皮肤不良反应(LTG-cADRs)的关联性。方法:通过计算机全面检索生物医学文献库PubMed、Em-base、The Cochrane Library、Medline、CNKI、VIP和万方数据库,检索时间截止至2018年7月24日,纳入探讨了HLA-A*31:01与LTG-cADRs相关性的研究,并采用RevMan 5.3软件进行Meta分析。结果:共纳入5项病例对照研究,123例LTG-cADRs癫痫患者,137例拉莫三嗪耐受(LTG-Tolerant)癫痫患者,2 837例正常人群。Meta分析结果显示,在与LTG-Tolerant组的比较中,HLA-A*31:01基因型与LTG所致的cADRs存在显著相关性(OR=2.87,95%CI:1.11～7.40,P=0.03)。而在与正常人群组的比较中,HLA-A*31:01基因型与LTG所致的cADRs不存在显著相关性(OR=1.34,95%CI:0.34～5.28,P=0.67)。结论:本研究证明,HLA-A*31:01基因型可能是LTG所致cADRs的遗传风险因素。
OBJECTIVE In recent years,a number of studies have examined the assoation between the human leukocyte antigen HLA-A*31:01 allele and cutaneous adverse drug reactions(cADRs)caused by lamotrigine(LTG).However,the rela-tionship between HLA-A*31:01 and cADRs remains unknown.This study aims to analyze this assoation in the published lit-erature.METHODS PubMed,Embase,the Cochrane Library,Medline,CNKI,VIP,Wanfang Database(from their incep-tion to July 24 th,2018)were searched for case-control studies.RevMan 5.3 software was used for meta-analysis.RESULTS-Five case-control studies with 123 LTG-cADRs patients,137 LTG-tolerant patients and 2 837 general were included.Meta-a-nalysis results showed that in comparison with the LTG-Tolerant group,a significant correlation was found between HLA-A*31:01 genotype and LTG-cADRs(OR=2.87,95%CI:1.11-7.40,P=0.03).When compared with population controlgroup,there was no significant assoation between the HLA-A*31:01 genotype and LTG-induced cADRs(OR=1.34,95%CI:0.34-5.28,P=0.67).CONCLUSION This study demonstrates that HLA-A*31:01 genotype may be a genetic risk factor for cADRs caused by LTG.
作者
梅冬
张晓燕
赵立波
王晓玲
MEI Dong;ZHANG Xiao-yan;ZHAO Li-bo;WANG Xiao-ling(Clinical Research Center,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China)
出处
《中国医院药学杂志》
CAS
北大核心
2019年第3期265-268,共4页
Chinese Journal of Hospital Pharmacy
基金
国家科技部重大新药创制(编号:2018ZX09721003)
首都医科大学附属北京儿童医院国家自然科学基金培育项目(编号:GPY201711)
