摘要
非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是以肝内细胞脂肪变性和过度沉积为主要特征的临床代谢应激性肝损伤,为常见的慢性肝病,也是导致严重肝病的诱因之一。但由于理想化NAFLD实验模型的匮乏,导致NAFLD的发病机制仍有待深入阐明,治疗药物研发相对滞后。因此,建立接近于临床疾病特征的NAFLD细胞动物实验模型,对于探索其发病机制和筛选评价相关候选药物具有重要意义。笔者将从体内体外角度,分别对NAFLD发展进程中相关实验性模型进行综述并深入分析其优缺点,为防治NAFLD创新药物研究提供充分理论依据和模型选择。
Nonalcoholic fatty liver disease(NAFLD),a clinical metabolic stress-induced liver injury,is expressed as a feature of intrahepatic cell steatosis and excessive fatty deposition.NAFLD is a rising cause of common chronic liver disease worldwide.However,due to the lack of idealized NAFLD experimental models,the pathogenesis of NAFLD remains to be elucidated and consequently the research and development of therapeutic drugs against NAFLD has been making a relatively slow progress.Therefore,the establishment of cell and animal models is of great significance for exploring its pathogenesis and screening relevant experimental drugs.In this paper,the experimental models involved in NAFLD are reviewed and its advantages and disadvantages are evaluated further in vitro and in vivo,which provides a sufficient theoretical basis and model selection for the investigation and development of innovative drugs against NAFLD.
作者
汪美汐
彭宗根
WANG Mei-xi;PENG Zong-gen(Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100050,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2019年第18期1457-1462,共6页
Chinese Pharmaceutical Journal
基金
十三五重大新药创制科技重大专项资助(2018ZX09711001-003-010)
中国医学科学院医学与健康科技创新工程资助(2017-I2M-3-012)
中国医学科学院北京协和医学院协和学者特聘教授项目资助(2016)
关键词
非酒精性脂肪性肝病
实验模型
疾病进展
药物研究
应用评价
nonalcoholic fatty liver disease
experimental model
disease progression
drug research
application evaluation
