摘要
目的:观察川芎嗪注射液对慢性阻塞性肺疾病(COPD)患者肺动脉高压的临床作用并探讨其可能机制。方法:将采集的确诊为COPD的22例患者随机分为2组(n=11):常规治疗组和川芎嗪治疗组,并随机抽取门诊体检正常者11例作为正常对照组。常规治疗组予以卧床休息、低流量吸氧、支气管舒张剂、糖皮质激素及抗生素等治疗,川芎嗪治疗组在常规治疗基础上加用川芎嗪注射液(60 mg/d静脉点滴),正常对照组不予任何治疗措施,治疗2周后检测3组的肺功能、动脉血气分析及肺动脉压,用敏感硫电极法检测血浆硫化氢(H_2S)的浓度。结果:1经过2周治疗后,常规治疗组和川芎嗪治疗组肺功能、动脉血气分析、肺动脉压等各项指标均比治疗前有明显改善,但川芎嗪治疗组优于常规治疗组(P<0.05);2川芎嗪组综合治疗后血浆H2S浓度明显高于治疗前和常规治疗组(P<0.01)。结论:川芎嗪注射液可能通过升高体内H_2S浓度,有效地改善COPD患者肺功能状态。
Objective: To observe the effects of ligustrazine hydrochloride injection( LHI) on pulmonary arterial hypertension in chronic obstructive pulmonary disease( COPD) patients and to investigate its possible mechanisms. Methods: Twenty-two cases of patients with COPD were randomly divided into conventional treatment group( group C) and ligustrazine treatment group( group L),11 persons were randomly selected from healthy subjects without lung disease served as normal control group( group N). Group C was given bed rest,low flow oxygen inhalation,bronchial diastolic agent,glucocorticoid and antibiotics and other conventional treatment,and group L was added with ligustrazine hydrochloride injection on the above mentioned basis treatment,group N was given no treatment.After 2 weeks,lung function,blood gas analysis and pulmonary arterial pressure were compared among the three groups,and the content of H_2S in plasma was tested with sensitive sulfur electrode method. Results: 1 After two weeks treatment,in group L and group C pulmonary function,blood gas analysis,pulmonary artery pressure were obviously improved,and group L was better than group C( P< 0. 05); 2 In group L the content of H_2S was increased( P < 0. 01),group C had no significant difference( P > 0. 05),and there was a significant difference between the two groups( P < 0. 01). Conclusion: Combination with LHI can effectively improve lung function. LHI may relieve hypoxic hypercapnia pulmonary hypertension induced by COPD through raising the content of H_2S.
出处
《中国应用生理学杂志》
CAS
CSCD
2016年第5期408-412,共5页
Chinese Journal of Applied Physiology
基金
浙江省中医药科技计划重点项目(2013ZZ011)
