摘要
心力衰竭是慢性心血管疾病终末期死亡的主要因素之一,心肌不良重构在心力衰竭的发生中起到关键性作用,而心肌纤维化是心肌不良重构的一个重要表现。越来越多的研究表明,表观遗传调控机制在心肌纤维化的发生及发展过程中发挥重要的作用。本文主要综述了DNA甲基化修饰、组蛋白修饰以及microRNA等表观遗传机制调控心肌纤维化发生发展的研究进展。
Heart failure is one of the leading causes of death for patients at the end stage of chronic cardiovascular disease. The adverse remodeling of the myocardium plays a critical role in the occurrence of heart failure, and myocardial fibrosis is an important manifestation of adverse cardiac remodeling. Increasing evidence indicates that the epigenetic regulatory mechanisms play important roles in the occurrence and development of myocardial fibrosis. This review focuses on the progress of research on epigenetic regulation, including DNA methylation, histone modification, and microRNA, in myocardial fibrosis.
作者
汪波
占贞贞
曾麒燕
WANG Bo;ZHAN Zhenzhen;ZENG Qiyan(Department of Biochemistry and Molecular Biology,Guangxi Medical University,Nanning 530021,China;Institute of Heart Failure,Shanghai East Hospital,Tongji University,Shanghai 200120)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第3期92-97,共6页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(81571541)
