摘要
目的比较雷贝拉唑与奥美拉唑治疗反流性食管炎的临床疗效。方法选取在我院诊治的反流性食管炎患者84例,随机分为对照组和研究组。对照组给予奥美拉唑治疗,研究组给予雷贝拉唑治疗。比较两组的临床疗效(症状缓解程度)、内镜下疗效、不良反应、24 h的p H<4反流次数及总时间等指标。结果研究组临床总有效率为92.86%,对照组为71.43%,差异有统计学意义(P<0.05);研究组内镜下疗效总有效率为95.24%,对照组为69.05%,差异有统计学意义(P<0.05)。两组治疗前后烧心症状评分比较,差异均有统计学意义(P<0.05);两组治疗前后反流症状评分比较,差异均有统计学意义(P<0.05)。研究组24 h的p H<4反流次数平均(10.26±2.41)次,反流时间平均(1.02±0.23)h,明显低于对照组的(25.81±4.32)次和(3.04±1.20)h,差异有统计学意义(P<0.05)。结论雷贝拉唑治疗反流性食管炎具有起效快、作用时间长、疗效稳定性高、安全性好及疗效佳等优点,值得临床推广。
Objective To compare the clinical effects of rabeprazole and omeprazole in treatment of reflux esophagitis. Methods A total of 84 cases of patients with reflux esophagitis were randomly divided into control group and research group. The control group were treated by omeprazole, the research group were treated by rabeprazole. The clinical effects, endoscopic clinical effects, adverse reactions, number of reflux, total time were compared. Results The effective rate of the research group(92.86%) was higher than the control group(71.43%)(P<0.05);The effective rate of the en-doscopic clinical effects for the research group (95.24%) was higher than the control group (69.05%)(P<0.05);The symptoms of heartburn scores for the two groups posttreatment were better than prior treatment (P<0.05); The reflux symptom scores for the two groups posttreatment were better than prior treatment(P<0.05);The number of reflux in 24 h with pH<4 of the research group (10.26±2.41) was lower than the control group (25.81±4.32)(P<0.05);The time of the research group(1.02±0.23)h was lower than the control group(3.04±1.20)h(P<0.05). Conclusion It has rapid on-set, long the effective time, clinical effect with high reliability, good safety and good clinical effect for the patients with reflux esophagitis treated by rabeprazole. It is valuable in clinical application.
出处
《中国现代医生》
2014年第35期42-44,共3页
China Modern Doctor
