摘要
目的分析探讨肝炎及肝硬化患者血清中降钙素原(procalcitonin,PCT)水平与其肝功能的关系。方法回顾性分析我院2012年12月~2013年12月收治的80例乙型肝炎病毒(hepatitis B virus,HBV)感染的肝炎及肝硬化患者,其中急性乙型肝炎(acute hepatitis B,AHB)患者20例,肝硬化(hepatic cirrhosis,HC)患者60例,分别在治疗前后检测患者外周血中PCT、白细胞计数、中性粒细胞计数及肝功能(ALT、AST、TBIL、PTA)水平,并对患者PCT与肝功能的关系进行评价。结果 AHB患者及HC患者治疗前PCT水平、白细胞计数、中性粒细胞计数明显高于治疗后,差异具有统计学意义(t=11.411、2.217、3.567,P<0.05);治疗后患者肝功能水平较治疗前明显改善,差异具有统计学意义(t=14.465、13.164、14.563、8.579,P<0.05);血清PCT水平与肝功能ALT、AST、TBIL呈正相关,与PTA水平呈负相关(r=0.877、0.964、0.859、-0.744,P<0.05)。结论乙型肝炎病毒感染的肝炎及肝硬化患者PCT水平与肝功能各指标具有相关性,对患者抗感染治疗及改善肝功能具有指导意义。
Objective To explore the relationship between the serum procalcitonin(PCT) level and liver function in pa-tients with hepatitis and liver cirrhosis. Methods A retrospective analysis of 80 cases of hepatitis B virus in our hospi-tal from December 2012 to December 2013 admitted (hepatitis B virus, HBV) infection in patients with hepatitis and liver cirrhosis, included acute hepatitis B (acute hepatitis B, AHB) infection in 20 patients and hepatic cirrhosis (hep-atic cirrhosis, HC) infection in 60 patients. PCT in peripheral blood, white blood cell count, neutrophil count and liver function tests (ALT, AST, TBIL, PTA) levels before and after treatments in patients, and the relationship between PCT and liver function of patients were evaluated. Results PCT level, white blood cell count and neutrophil count in AHB patients and HC patients before treatment were significantly higher than that after treatment, there was statistically sig-nificant difference (t=11.411, 2.217, 3.567, P<0.05); After treatment, patients liver function was significantly improved than before treatment, the difference was statistically significant (t=14.465, 13.164, 14.563, 8.579, P<0.05);The level of PCT in serum and liver function of ALT, AST, TBIL were positively correlated, negatively correlated with the level of PTA (r=0.877, 0.964, 0.859, -0.744, P<0.05). Conclusion There is correlation between PCT level and each index in patients with hepatitis B virus infection and liver cirrhosis, which have significance in treatment patients with infection and liver function disorder.
出处
《中国现代医生》
2014年第35期18-20,24,共4页
China Modern Doctor
关键词
肝炎
肝硬化
降钙素原
肝功能
关系
Hepatitis
Liver cirrhosis
Procalcitonin
Liver function
Relationship
