摘要
亚硒酸钠目前已被广泛应用于防治大骨节病和克山病,且疗效显著。开发高效低毒、安全的硒制剂供临床使用业已引起化学家、生物化学家、微生物学家、临床医学和畜牧兽医学家、药理学家等广泛的兴趣,近年也取得了一定进展。富硒酵母作为一种生物硒制剂已在美国市场上出售,据报导其含硒量为每片50～200μg,但其在人体内的利用率。
The selenium enriched yeast containing 4700ppm of selenium was prepared and dialyzable selenium compositionwas studied.The dynamics of seleniumenriched yeast and sodium selenite intwo kinds of dosage in animal bloodwas observed and the half-life of sel-enium in blood,selenium deposition intissues and the median lethal dose wasdetermineed.The deposition of the two speciesof selenium in human hair and the ur-inary excertion of selenium was alsomeasured.The bioavailability and bioac-tivity of the two species of seleniumwas studied comparatively in humanbody,using selenium content and glut-athione peroxdase activity in blood asa index,we compared the relation bet-ween the two species of selenium andX-ray efficacious rates of therapyingKashin-Beck's disease respectively.The results revealed that both of bioav-ailability and bioactivity of seleniumenriched yeast in human body werehigher than that of sodium selenite.
出处
《中华地方病学杂志》
CAS
1986年第2期-,共6页
Chinese Journal of Endemiology
