摘要
目的研究ERα蛋白在乳腺癌细胞中的定位情况以及质膜ERα表达的临床病理意义。方法免疫组化法检测ERα蛋白表达量及细胞内定位,统计分析质膜ERα蛋白与患者临床病理特征之间的相关性。结果 ERα免疫组化染色阳性定位主要位于细胞核,部分病例可观察到细胞质膜部位着色。质膜ERα与N分期及HER2评分有关,呈等级相关(P<0.05)。质膜ERα阳性患者无进展生存期较短(P<0.05)。结论质膜ERα与患者淋巴结转移及HER2蛋白表达相关。质膜ERα表达可能是一种独立的预后不良因素。
Objective To investigate the localization of ER alpha protein in breast cancer cells and the clinicopathological significance of the expression of plasma membrane ERα.Methods The immunohistochemical method was used to detect the expression quantity and intracellular localization of ER alpha protein,and the correlation between the clinical and pathological features of the patients was statistically analyzed.Results The immunohistochemical staining was mainly located in the nucleus,and some cases were observed in the plasma membrane.The plasma membrane ER was related to N staging and HER2 score(P<0.05).The survival period was shorter(P<0.05).Conclusion The plasma membrane ER is associated with lymph node metastasis and HER2 protein expression in breast cancer.The expression of plasma membrane ER may be an independent prognostic factor.
作者
吕丽
王齐敏
张丽
张健
王莉芬
LV Li;WANG Qi-min;ZHANG Li;ZHANG Jian;WANG Li-fen(Department of Pathology,the Second Hospital of Dalian Medical University,Dɑliɑn 116027,China)
出处
《诊断病理学杂志》
2019年第4期224-226,230,共4页
Chinese Journal of Diagnostic Pathology
基金
辽宁省自然科学基金(项目编号:2015020312)
关键词
质膜雌激素受体
乳腺癌
免疫组化
Plasma membrane ERα
Breast cancer
Immunohistochemistry
