摘要
目的研究微晶纤维素(MCC)对疏风解毒配方提取物粉末(SFJDE)直压性能的影响。探讨压片前粉体的基础物理性质与其功能性质之间的相关性。方法 SFJDE和MCC按照不同比例混合后,分别测定混合粉体物理性质和在不同压力下的压缩参数。采用线性回归和偏最小二乘法(PLS)对粉末基础物理性质和功能性参数进行处理分析。结果 SFJDE中MCC的加入量与粉末的含水量(MC)、松密度(ρb)、孔隙率(ε)等呈现较好的线性关系(r2≥0.991 9),与流动性指标Hausner比(HR)、Carr’s指数(CI)呈现良好的正相关性(r2≥0.8342);表征粉体压缩性的参数压缩比(CR)、屈服应力(Py)逐渐降低,单位有效功(Esp)、参数a逐渐升高;表征粉体成型性参数kA逐渐增大,kB逐渐变小。PLS分析粉体的基本物理性质MC、ρb、振实密度(ρt)、真密度(ρtrue)、中值粒径(D0.5)对这些参数影响最大,而粒径分布(span)、HR、CI对其影响较小,但这3个指标对于表征粉体破碎和重排参数ab和f的影响最大。结论 MCC的增加降低了SFJDE的流动性,提高了SFJDE的压缩和成型能力,在使用的过程中应该要注意其流动性和压力敏感性的影响。
Objective To study the influence of microcrystalline cellulose(MCC)on the direct pressure properties of powder extracted from Shufeng Jiedu formula(SFJDE),and discuss the correlation between the basic physical properties and its functional properties of the powder before compression.Methods SFJDE and MCC was mixed in different proportions,the physical properties of the mixed powder and the compression parameters under different pressures were determined.The basic physical properties and functional parameters of the powder were processed and analyzed by linear regression and partial least squares(PLS).Results The addition of MCC in SFJDE showed a good linear relationship with the moisture content(MC),bulk density(ρb),and porosity ratio(ε)of the powder(r2≥0.991 9),and showed a good positive correlation with Hausner ratio(HR)and Carr’s index(CI)of the powder flow index(r2≥0.834 2).The parameters of powder compressibility compaction ratio(CR)and yield pressure(Py)gradually decreased,Unit effective work(Esp)and paramter a gradually increased;The powder compaction parameter kA was gradually increased,and kB was gradually decreased.The basic physical properties of MC,ρb,tap density(ρt),true density(ρtrue),and particle size(D0.5)of the powder had the obvious impact on these parameters by PLS analysis,while size distribution(span),HR,CI had little effect on it.However,span,HR,and CI had the obvious influence on the parameters ab and f,which characterized powder breakage and rearrangement.Conclusion The increase of MCC reduces the fluidity of SFJDE,improves the compressibility and compactibility of the powder,therefore,we should pay attention to the influence of fluidity and pressure sensitivity during the process of use.
作者
余雅婷
赵立杰
徐君杰
王优杰
冯怡
YU Ya-ting;ZHAO Li-jie;XU Jun-jie;WANG You-jie;FENG Yi(Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Sinotherapeutics Inc,Shanghai 201203,China)
出处
《中草药》
CAS
CSCD
北大核心
2019年第17期4041-4050,共10页
Chinese Traditional and Herbal Drugs
关键词
疏风解毒
微晶纤维素
压缩性
成型性
直接压片
片剂
dispersing wind and removing toxin
microcrystalline cellulose
compressibility
compactibilty
direct compression
tablet
