摘要
目的探讨颅脑外伤患者迟发性颅内出血现象与凝血机制异常的关系。方法选取2016年1月-2017年10月在山东省单县东大医院收治的76例颅脑外伤患者为研究对象,根据患者是否出现迟发性颅内出血,将其分为出血组23例和未出血组53例。比较两组影响因素以及迟发性颅内出血的相关危险因素,同时比较两组凝血功能相关指标,包括凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶原国际标准化比率(INR)、血小板计数(PLT)等。结果出血组TT、PT、APTT及INR等指标均明显高于未出血组,而出血组的PLT水平则明显低于未出血组,差异有统计学意义(P<0.05);且当患者凝血指标异常数量≥2时,其在颅脑外伤后发生出血症状的概率更高。结论若患者凝血功能存在异常情况,颅脑外伤迟发性颅内出血发生的风险增高,尤其当患者出现2项或者是2项以上指标异常时更加容易导致颅内出血,因此在临床上医生以及相关护理人员应该高度重视并进行及时有效的预防。
Objective To investigate the relationship between delayed intracranial hemorrhage and abnormal coagulation mechanism in patients with craniocerebral trauma.Methods Seventy-six patients with craniocerebral trauma admitted to Shan County Dongda Hospital of Shandong from January 2016 to October2017 were selected as the research subjects.According to whether the patients had delayed intracranial hemorrhage,they were divided into 23 cases of bleeding group and 53 cases of non-bleeding group.The influencing factors and risk factors associated of delayed intracranial hemorrhage were compared between the two groups.Meanwhile,the related indexes of coagulation function,including thrombin time(TT),prothrombin time(PT),activated partial prothrombin time(APTT),international standardized ratio of prothrombin(INR),platelet count(PLT)and so on,were compared between the two groups.Results TT,PT,APTT and INR in the bleeding group were significantly higher than those in the non-bleeding group,while the PLT level in the bleeding group was significantly lower than that in the non-bleeding group,the differences were statistically significant(P<0.05),and when the number of abnormal coagulation index was larger than or equal to two,the probability of hemorrhagic symptoms after traumatic brain injury was higher.Conclusion If the patient’s coagulation function was abnormal,the risk of delayed intracranial hemorrhage in craniocerebral trauma increased,especially when the patient has 2 or more indicators,which was more likely to cause intracranial hemorrhage.Therefore,the doctor and nursing should attach great importance to the prevention in a timely and effective manner.
作者
郭良波
GUO Liang-bo(Department of Neurosurgery,Shan County Dongda Hospital of Shandong,Heze Shandong Province 274300,China)
出处
《中国城乡企业卫生》
2019年第10期43-46,共4页
Chinese Journal of Urban and Rural Enterprise Hygiene
关键词
颅脑外伤
迟发性
颅内出血
凝血
Traumatic brain injury
Delayed type
Intracranial hemorrhage
Blood coagulation
