摘要
目的 观察和评价左氧氟沙星方案在耐多药结核治疗中的疗效。方法 采用随机配对分组法 ,将 71例耐多药结核患者分为治疗组 ( 3 6例 )和对照组 ( 3 5例 )。化疗方案 :治疗组以左氧氟沙星为主 ,另选用 3种以上敏感药或既往未用过的新药 ,对照组不用左氧氟沙星 ,其它药物同治疗组。结果 治疗 3月后 ,治疗组痰菌阴转率 61.1% ,对照组为 3 7.1% ,疗程结束时 ,痰菌阴转率分别为 80 .6%和 5 1.4% ,两组比较有显著性差异 (P <0 .0 1～ 0 .0 5 )。治疗组药物副反应率 19.4% ,对照组为 17.1% ,两组无明显差异 (P >0 .0 5 )。结论 左氧氟沙星方案治疗耐多药结核安全有效 ,值得应用。
Objectives To observe and evaluate the curative effect of levofloxacin on multi-drug resistant tuberculosis(MDR-TB). Methods 71 cases with MDR-TB were divided into experimental group (n=36) and control group (n=35) randomly by paired design. Chemotherapy schedule: In trial group, in addition to levofloxacin, more than 3 sensitive drugs or new drugs which were not used before were used. In control group, levofloxacin was not used, while other drugs were the same to trial group. Results Three months later, the sputum negative conversion rates were 61.1% in trial group and 37.1% in control group. At the end of treatment, the rates were 80.6% and 51.4% respectively. The difference between two groups was significant (p<0.01,or p<0.05). The adverse reaction rates of drug were 19.4% (trial group) and 17.1% (control group). The difference between two groups was insignificant (P>0.05). Conclusions The therapeutic schedule with levofloxacin is effective and safe for MDR-TB .
出处
《实用全科医学》
2004年第1期35-36,共2页
Applied Journal Of General Practice
