摘要
目的 :研究肺癌和正常肺组织中基质金属蛋白酶 2 (MMP 2 )和MMP 9的表达。方法 :采用免疫组织化学EnVision方法 ,对 71例肺癌标本和 31例正常肺组织检测MMP 2和MMP 9的表达。结果 :71例肺癌标本中 ,小细胞肺癌 (SCLC) 4例 ,MMP 2表达阳性 3例 (75 0 % ) ,MMP 9表达阳性 2例(5 0 0 % ) ;非小细胞肺癌 (NSCLC)有 6 7例 ,年龄 4 0岁以上 6 4例 ,MMP 2表达阳性 39例 ,阳性率 6 0 9%(39 6 4) ;MMP 9表达阳性 4 6例 ,阳性率 71 9% (4 6 6 4)。正常肺标本 31例 ,年龄 4 0岁以下MMP 2和MMP 9表达均为阴性 ,年龄在 4 0岁以上 2 6例 ,MMP 2阳性表达 9例 ,阳性率 34 6 % (9 2 6 ) ,MMP 9阳性表达 10例 ,阳性率 38 5 % (10 2 6 ) ;4 0岁以上NSCLC标本的MMP 2和MMP 9阳性表达与正常肺标本比较 ,差异均有显著意义。结论 :在NSCLC中高表达的MMP 2和MMP 9均是好的肿瘤标记物 ,但是 ,MMP 9阳性率比MMP 2更高 ,因此MMP 9的检测具有更大的临床意义。
Objective To study the expression of matrix metalloproteinase 2(MMP 2) and MMP 9 in lung cancer.Methods EnVision immunohistochemical technique was used to detect the expression of MMP 2 and MMP 9 in 71 cases of lung cancer and 31 cases of normal lung tissue.Results Of 71 patients,4 cases were small cell lung cancer,in which the positive immunoreactivity was demonstrated in 3(75 0%) for MMP 2 and in 2(50 0%) for MMP 9.Sixty seven cases were non small cell lung cancer(NSCLC) in which 64 cases were over 40 years,the positive immunoreactivity was demonstrated in 39(60 9%) for MMP 2 and in 46(71 9%) for MMP 9.Of 31 normal lung specimens,the positive immunoreactivities of MMP 2 and MMP 9 were all negative in cases of below 40 years.Of 26 cases of over 40 years the positive immunoreactivity was demonstrated in 9(34 6%) for MMP 2 and in 10(38 5%) for MMP 9.The expression of MMP 2 and MMP 9 in NSCLC was a significantly difference comparison with normal lung specimens.Conclusion MMP 2 and MMP 9 have high expression in NSCLC and they were good tumor markers.The positive rate of MMP 9 was higher than MMP 2,and therefore,detection of MMP 9 has more clinical significance.
出处
《肿瘤防治杂志》
2003年第9期920-922,共3页
China Journal of Cancer Prevention and Treatment
