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趋化因子及其受体与GVHD研究进展 被引量:1

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摘要 趋化因子为一分子量为 811kD的小分子蛋白质超家族 ,其受体为Gi Go蛋白偶联受体 ,目前已发现有19个。趋化因子及其受体与GVHD的关系是目前移植免疫研究的一个新兴领域。实体器官移植后趋化因子有一时相性表达 ,但CXCL8(IL 8)与骨髓移植后GVHD的关系尚有争议。趋化因子及受体表达与GVHD发生的组织选择性及慢性GVHD病变的发生有关。CCL3(MIP 1α)及其受体CCR5对GVHD中自身抗体产生、受体特异性的CTL的组织选择性募集及活化等过程都具有重要作用。
作者 何静 陈燕
出处 《国外医学(生理病理科学与临床分册)》 2003年第6期647-649,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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