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JAB1研究进展 被引量：2

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摘要 JAB1可通过与AP 1特异位点的结合形成稳定复合物 ,促进靶基因的反式激活。JAB1可与三大类蛋白质相互作用 :①COP9信号体亚单位 :COP9信号体 1、COP9信号体 2、COP9信号体 4、COP9信号体 7。②细胞周期调节蛋白 :p2 7Kip1、MIF。③AP 1转录调节蛋白 :c Jun ,LFA 1,LHR ,PR ,SRC 1,Bcl 3,p5 3,HPO ,HIF。JAB1参与许多信号转导通路 ,包括调节植物的光信号、线虫的幼虫发育、整合素信号、细胞周期调控和甾体类激素的信号转导。
作者 许冰 胡维新
机构地区 中南大学湘雅医学院分子生物学研究中心
出处 《国外医学（生理病理科学与临床分册）》 2003年第6期608-611,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 国家自然科学基金 (3 9880 0 2 1)
关键词 JAB1 COP9信号体 信号转导
分类号 Q512 [生物学—生物化学]
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参考文献20

  • 1Seeger M, Kraft R, Ferrell K, et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits [ J]. FASEB, 1998,12 (6): 469-478. 被引量：1
  • 2Wei N, Tsuge T, Serino G, et al. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex [J]. Curr Biol, 1998,8(16): 919-922. 被引量：1
  • 3Aravind L, Ponting CP. Homologues of26S proteasome subunits are regulators of transcription and translation [ J]. Protein Sci, 1998,7:1250-1254. 被引量：1
  • 4Mahalinggam S. HIV-1 Vpr interacts with a human 34-kDa mov34 homologue,a cellular factor linked to the G2/M phase transition of the mammalian cell cycle [ J ]. Proc Natl Acad Sci, 1998,95:3419-3424. 被引量：1
  • 5Kapelari B, Bech-Otschir D, Hegerl R, et al. Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome [ J ]. Mol Biol, 2000,300: 1169-1178. 被引量：1
  • 6Kwok SF, Solano R, Tsuge T, et al. Arabidopsis homologs of a cJun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations [ J]. Plant Cell, 1998, 10( 11 ):1779-1790. 被引量：1
  • 7Tomoda K, Kubota Y, Arata Y, et al. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jabl/CSN5 and the COP9 signalosome complex [ J ]. Biol Chem, 2002,277 ( 3 ): 2302-2310. 被引量：1
  • 8Sui L, Dong Y, Ohno M, et al. Jabl expression is assnciated with inverse expression of p27 ( kipl ) and poor prognosis in epithelial ovarian tumors [J]. Clin Cancer Res, 2001,7(12) :4130-4135. 被引量：1
  • 9Yang HY, Zhou BP, Hung MC, et al. Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27 [ J ]. J Biol Chem, 2000, 275 (32): 24735-24739. 被引量：1
  • 10Kleemann R, Hausser A, Geiger G, et al. Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jabl [J]. Nature, 2000, 408(6809): 211-216. 被引量：1

同被引文献15

  • 1张锋,曹华.Jab1在喉鳞状细胞癌中的表达及临床意义[J].山东大学耳鼻喉眼学报,2007,21(2):144-146. 被引量：2
  • 2Seeger M,Kraft R, Ferrell K, et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB, 1998,12:469-478. 被引量：1
  • 3Fukumoto A, Ikeda N, Sho M, et al. Prognostic significance of localized p2?Kipl and potential role of Jab1/CSN5 in pancreatic cancer. Oncol Rep, 2004, 11 : 277-284. 被引量：1
  • 4Sui L, Dong Y, Watanabe Y,et al. Clinical significance of Skp2 expression, alone and combined with Jabl and p27 in epithelial ovarian tumors. Oncol Rep, 2006,15:765-771. 被引量：1
  • 5Esteva FJ, Sahin AA, Rassidakis GZ, et al. Jun activation domain binding protein 1 expression is associated with low p27 (Kip1) levels in node-negative breast cancer. Clin Cancer Res, 2003, 9:5652-5659. 被引量：1
  • 6Osoegawa A, Yoshino I, Kometani T, et al. Overexpression of Jun activation domain-binding protein 1 in nonsmall cell lung cancer and its significance in p27 expression and clinical features. Cancer, 2006,107 : 154-161. 被引量：1
  • 7Patil MA, Gutgemann I, Zhang J, et al. Array-based comparative genomic hybridization reveals recurrent chromosomal aberrationsand Jabl as a potential target for 8q gain in hepatoeellular carcinoma. Carcinogenesis ,2005,26 : 2050-2057. 被引量：1
  • 8Marrero JA, Fontana R J, Barrat A, et al. Prognosis of hepatocellular carcinoma: comparison of 7 staging systems in an American cohort. Hepatology, 2005, 41: 707-716. 被引量：1
  • 9Parkin DM, Bray F, Feday J, et al. Global cancer statistics, 2002. CA Cancer J Clin, 2005, 55 : 74-108. 被引量：1
  • 10Feitelson MA, Sun B, Satiroglu Tufan NL, et al. Genetic mechanisms of hepatocarcinogenesis . Oncogene, 2002, 21: 2593 -2604. 被引量：1

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国外医学（生理病理科学与临床分册）
2003年 第6期

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