摘要
目的 探讨隐匿型肾小球肾炎外周血淋巴细胞CD44,CD5 4的表达与疾病的关系。方法 采用流式细胞全血免疫荧光直标术对 2 5例隐匿型肾小球肾炎患者外周血进行CD44,CD5 4标记后 ,上流式细胞仪检测。结果 隐匿型肾小球肾炎患者外周血淋巴细胞CD44,CD5 4的表达显著高于正常对照 (P <0 .0 1 ) ,而且肉眼血尿组CD44,CD5 4的表达显著高于尿检异常组 (P <0 .0 1 )。结论 粘附分子CD44,CD5 4可能介导和参与了隐匿型肾小球肾炎的发生及发展过程 ,外周血淋巴细胞CD44,CD5 4的检测可为临床隐匿型肾小球肾炎的诊断和治疗提供分子依据。
Objective To investigate the role of CD44,CD54 in peripheral blood lymphocyte (PBL)of patients with latent glomerulonephritis. Methods The CD44,CD54 of peripheral blood was labelled by whole blood immunofluorescence direct-labelled technigue and detected by flow cytometer (FCM) in 25 patients with latent glomerulonephritis.Results The expression of CD44,CD54 in PBL of patients with latent glomerulonephritis was significantly higher than the control ( P <0.01); that in the patients with gross hematuria was higher than in the patients with abnomal urione analyses ( P <0.01).Conclusion Adhesion molecules(AM) of CD44,CD54 might play an important role in latent glomerulonephritis, and the detection of CD44,CD54 in PBL might provide molecular grounds for diagnosis and treatment of latent glomerulonephritis.
出处
《临床军医杂志》
CAS
2003年第6期22-23,共2页
Clinical Journal of Medical Officers
