摘要
目的:探讨Ⅲ期宫颈鳞癌单纯同步放化疗与诱导化疗后同步放化疗的远期疗效及预后。方法:收集2006年2月10日至2012年10月20日湖北医药学院附属随州医院收治的247例Ⅲ期宫颈鳞癌患者的完整随访/病历资料。根据治疗方式不同,分为同步组和诱导组,对两组的疗效及预后进行对比分析。结果:所有患者平均中位随访时间5年,同步组与诱导组3年和5年总体生存率分别为82.0%和61.2%,83.3%和64.2%,两组间无统计学差异(P=0.630);单因素分析显示:肿块长径、淋巴结转移是影响生存的因素。COX多因素分析显示淋巴结转移是预后独立影响因素。两组患者局部复发率、病死率、远处转移率、近远期不良反应无统计学差异(P>0.05)。结论:Ⅲ期宫颈鳞癌患者同步放化疗与诱导化疗后同步放化疗疗效及不良反应发生率相当,淋巴结转移是影响生存期的独立影响因素。
Objective To investigate the long term efficacy and prognosis of stageⅢcervical squamous cell carcinoma treated by concurrent chemoradiotherapy and concurrent chemoradiotherapy after induction chemotherapy.Methods Complete follow-up/medical records of 247 patients with stage III cervical squamous cell carcinoma admitted to Suizhou Hospital affiliated to Hubei Medical College from February 10,2006 to October 20,2012.According to different treatment methods,they were divided into synchronous group and induction group.The curative effect and prognosis of the two groups were compared and analyzed.Results The median follow-up time was 5 years for all patients.The 3 year and 5 year overall survival rates of the synchronous group and the induction group were 82.0%and 61.2%,83.3%and 64.2%,respectively.There was no statistical difference between the two groups(P=0.630).Univariate analysis showed that the tumor size and lymph node metastasis were the factors affecting survival(P<0.05).COX multivariate analysis showed that lymph node metastasis was an independent prognostic factor.There was no significant difference in mortality,local recurrence,distant metastasis,short-term and long-term side effects between the two groups(P>0.05).Conclusion The efficacy and adverse reactions of concurrent chemoradiotherapy for stage III cervical squamous cell carcinoma was similar to that of induction chemoradiotherapy.Lymph node metastasis was an independent factor affecting survival.
作者
谢辉
陈玉容
郑洁
周方正
XIE Hui;CHEN Yu-rong;ZHENG Jie;ZHOU Fang-zheng(Department of Oncology,Suizhou Hospital,Hubei University of Medicine;Department of Obstetrics and Gynecology,Maternal and Child Health Hospital,Suizhou,Hubei 441300,China)
出处
《湖北医药学院学报》
CAS
2019年第3期259-263,共5页
Journal of Hubei University of Medicine
关键词
期
宫颈癌
同步放化疗
诱导化疗
生存分析
预后
StageⅢ
Cervical cancer
Concurrent chemoradiotherapy
Induction chemotherapy
Survival analysis
Prognosis
