西格列汀在糖尿病治疗中的药理作用及临床疗效观察被引量：1

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摘要目的分析和研究西格列汀治疗糖尿病的药理作用和临床疗效。方法选取104例2型糖尿病患者分为两组,分别口服阿卡波糖和西格列汀治疗,观察两组治疗前后空腹、餐后2h静脉血糖变化和糖化血红蛋白变化。结果两组治疗3个月后空腹血糖、餐后2h血糖以及糖化血红蛋白水平均明显降低,观察组各项指标明显低于参照组,差异对比有统计学意义(P<0.05)。结论使用西格列汀治疗糖尿病具有良好的治疗效果,可有效降低患者血糖和糖化血红蛋白水平。

作者柴辉

机构地区河南省孟州市人民医院

出处《首都食品与医药》 2019年第2期49-49,共1页 Capital Food Medicine

关键词 2型糖尿病西格列汀药理作用临床疗效

分类号 R587.1 [医药卫生—内分泌]

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1王小红.磷酸西格列汀联合二甲双胍治疗2型糖尿病临床疗效观察[J].临床合理用药杂志,2017,10(2):65-66. 被引量：11
2范爱红.西格列汀联合二甲双胍治疗2型糖尿病的临床疗效观察[J].临床合理用药杂志,2017,10(31):75-76. 被引量：8
3李寅辉,杨晶晶,董丽明,樊勇.西格列汀治疗2型糖尿病疗效和安全性的Meta分析[J].中国糖尿病杂志,2014,22(10):907-913. 被引量：10
4王栋栋,魏彤,何素梅,张冠英,陈肖,魏群利.西格列汀延缓或阻止2型糖尿病肾病进展的实验研究[J].中国临床药理学杂志,2016,32(1):45-47. 被引量：27

二级参考文献37

1Brubaker PL, Drucker DJ. Minireview: gIucagon-like peptdes regulate cell proliferation and apoptosis in the pancreas, gut and central nervous system. Endocrinology, 2004, 145: 2653-2659. 被引量：1
2Baggio I.L, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology, 2007,132 : 2131 2157. 被引量：1
3Cho YM, Kieffer TJ. K-cells and glucose-dependent insulino- tropic polypeptide in health and disease. Vitam Horm, 2010, 84:111q50. 被引量：1
4Atkins D, Best D, griss PA, et al. Grading quality of evidence and strength of recommendations. BMJ, 2004,328 : 1490. 被引量：1
5Aschner P, Kipnes MS, Lunceford JK, et al. Effect of the dipep tidyl peptidase-4 inhibitor sitagliptin as monotherapy on glyce mic control in patients with type 2 diabetes. Diabetes Care, 2006,29:2632 2637. 被引量：1
6Russell Jones D, Cuddihy RM, Hanefeld M, et al. Efficacy and safety of exenatide once weekly versus metformin, pioglita- zone, and sitagliptin used as monotherapy in drug naive pa tients with type 2 diabetes(DURATION-4) :a 2g-week double- blind study. Diabetes Care, 2012,35 : 252 258. 被引量：1
7Fonseea V, Staels B, Morgan JD, et al. Efficacy and safety of sitagliptin added to ongoing metformin and pioglitazone combi- nation therapy in a randomized, placebo controlled, 26-week trial in patients with type 2 diabetes. J Diabetes Complications, 2013,27 : 177-183. 被引量：1
8Dobs AS,Goldstein BJ,Aschner P, et al. Efficacy and safety of sitagliptin added to ongoing metformin and rosiglitazone corn-bination therapy in a randomized placebo-controlled 54-week trial in patients with type 2 diabetes. J Diabetes, 2013, 5: 68-79. 被引量：1
9Williams-Herman D, Johnson J, Teng R, et al. Efficacy and safety of sitagliptin and metformin as initial combination thera- py and as monotherapy over 2 years in patients with type 2 dia- betes. Diabetes Obes Meta, 2010,12 : 442-451. 被引量：1
10Mohan V, Yang W,Son HY, eta[. Efficacy and safety of sita- gliptin in the treatment of patients with type 2 diabetes in Chi- na, India, and Korea. Diabetes Res Clin Pract, 2009, 83 106-116. 被引量：1