摘要
目的观察通过对高危人群进行鼻前庭涂抹莫匹罗星对耐甲氧西林金黄色葡萄球菌(MRSA)去定植的效果。方法采用回顾性对照试验,选取医院2014年住院患者中的高危人群采用每日2次、共5 d的莫匹罗星鼻前庭涂抹,同时选取2011年至2013年住院患者中的高危人群作为对照组。结果 2011年、2012年、2013年、2014年医院共发生多重耐药菌96,125,167,183例,其中MRSA分别为19,25,55,35例,构成比分别为19.79%,20.00%,32.93%,19.13%。多重耐药菌检出标本类型以痰标本为主,构成比达50.00%以上;这4年中MRSA在痰液中的检出率分别为47.37%,52.00%,52.73%,28.57%。结论 MRSA在医院高危人群中的定植现象较常见,鼻腔涂抹莫匹罗星能有效去定植,减少MRSA的检出。
Objective To smear mupirocin in nasal area of the high-risk population to achieve the decolonization of methicillin-resis-tant staphylococcus aureus(MRSA). Methods As a historical controlled trial, the inpatients from 2011 to 2013 were selected as the control group, and the inpatients in 2014 as the experimental group with 5 d of mupirocin nasal smearing ( twice per day ) among high-risk inpatients. Results The number of inpatients who suffering multi-drug resistant bacteria were 96 cases, including 19 cases of MRSA with a constituent ratio of 19. 79% in 2011; In 2012, 2013 and 2014, the number of inpatients who suffering multi-drug resistant bacteria, the number of MRSA and the constituent ratio of MRSA were 2012:125, 25, 20. 00%;2013:167, 55, 32. 93%;2014:183, 35, 19. 13%. The main type of multiple resistant bacteria was sputum, consisting more than 50%; he detection rate of MRSA in sputum of the 4 years were 47. 37%, 52. 00%, 52. 73%, 28. 57%. Conclusion The colonization of MRSA is very common. Smearing mupirocin in nasal area can effectively decolonize and reduce the occurrence of MRSA.
出处
《中国药业》
CAS
2015年第21期211-212,共2页
China Pharmaceuticals
关键词
多重耐药菌
耐甲氧西林的金黄色葡萄球菌
去定植
莫匹罗星
multi drug resistant bacteria
methicillin-resistant staphylococcus aureus
decolonization
mupirocin
