摘要
过敏性紫癜(HSP)是一种以皮肤紫癜、瘀点、瘀斑为主要表现的变态反应性小血管炎,好发于儿童,发病原因至今不明。近年来认为各种感染,包括细菌、病毒、支原体/衣原体、真菌等微生物以及寄生虫感染是过敏性紫癜的主要诱因,由感染因素引发的过敏性紫癜发生肾损害的概率较高,严重影响患者的预后。大量研究显示,对HSP患者进行抗感染治疗后患者病情缓解。临床医师在治疗HSP时除了要积极治疗原发病外,还要评估患者有无其他脏器(尤其是肾脏)受累,及早进行干预以改善预后。
Allergic purpura(Henoch-Schnlein Purpura,HSP)is an allergic microvasculitis characterized by skin purpura and petechiae.This disease tends to strike children more,and the cause is still unknown.In recent years,all kinds of infections,including bacteria,viruses,mycoplasma,chlamydia,fungi and other microbes and parasites infections have been considered as the main causes of allergic purpura.The incidence of renal damage of allergic purpura caused by infection factors is higher,which seriously affects the prognosis.A large number of studies have shown that anti-infection treatment can alleviate the HSP.Therefore,clinicians need to actively treat the primary disease,and evaluate whether there are other organs involved,especially the kidney while treating allergic purpura,and make early interventions to improve the prognosis.
作者
潘春雨
冯爱平
PAN Chunyu;FENG Aiping(Department of Dermatology,Union Hospital of Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430000,China)
出处
《医学综述》
2019年第12期2416-2421,2426,共7页
Medical Recapitulate
关键词
过敏性紫癜
感染
致病机制
预后
Henoch-Schonlein purpura
Infection
Pathogenic mechanism
Prognosis
