摘要
肝脏缺血再灌注损伤是导致肝脏移植术后肝功能障碍和肝衰竭的重要原因,其发生机制有钙超载、氧化应激、炎症损伤、微循环障碍等。血红素加氧酶1(HO-1)是细胞内广泛表达的血红素降解的关键限速酶,可在细胞受到各种应激刺激时诱导性表达。HO-1减轻肝脏缺血再灌注损伤有多种机制,如抗氧化、抗凋亡、抗炎症、促自噬等,是细胞重要的内源性防御分子,其代谢产物胆绿素、一氧化碳和游离铁也可对肝脏缺血再灌注损伤起保护作用。
Hepatic ischemia reperfusion injury is the main cause of liver dysfunction and liver failure after liver transplantation.Multiple mechanisms such as calcium overload,oxidative stress,inflammatory injury and microcirculation dysfunction are involved.Heme oxygenase 1(HO-1)is the key speed limit enzymes of heme degradation widely expressed in cells,which can be induced by a variety of stress stimuli.HO-1 can alleviate hepatic ischemia-reperfusion injury through many mechanisms such as anti-oxidation,anti-apoptosis,anti-inflammation,pro-autophagy and so on,which is an important endogenous defense molecule in cells.Besides,its metabolites such as biliverdin,carbon monoxide(CO)and free iron(Fe2+)also have protective effects on hepatic ischemia reperfusion injury.
作者
杨诺
李文
YANG Nuo;LI Wen(First Clinical Medical College,Capital Medical University,Beijing 100069,China;Department of Cell Biology,Basic Medical College,Capital Medical University,Beijing 100069,China)
出处
《医学综述》
2019年第12期2289-2293,2298,共6页
Medical Recapitulate
基金
国家自然科学基金青年科学基金(81100310)
关键词
肝脏缺血再灌注损伤
血红素加氧酶1
肝移植
Hepatic ischemia reperfusion injury
Heme oxygenase 1
Liver transplantation
