摘要
目的比较^(131)I与他巴唑治疗甲状腺功能亢进的临床疗效。方法选取2012年1月至2013年1月广西医科大学第四附属医院收治的86例甲状腺功能亢进患者为研究对象,依据随机数字表法分为观察组与对照组,每组43例。观察组患者接受^(131)I治疗,对照组接受他巴唑治疗。比较两组患者的临床疗效,治疗前后甲状腺功能亢进指标[促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)]及治疗后低钾发生率和复发率。结果观察组患者治疗总有效率[88.4%(38/43)]显著高于对照组[69.8%(30/43)],差异有统计学意义(P<0.05);观察组患者治疗后低钾发生率显著高于对照组[25.6%(11/43)比4.7%(2/43)],而复发率显著低于对照组[16.3%(7/43)比51.2%(22/43)],差异均有统计学意义(P<0.05)。两组患者治疗后3个月的FT3、FT4呈下降趋势,且不同时间点观察组低于对照组;两组患者治疗后3个月的TSH呈上升趋势,且各时间点观察组高于对照组。两组不同时间点比较差异有统计学意义(P<0.05)。结论^(131)I治疗甲状腺功能亢进的临床疗效显著,安全性高,能显著改善患者甲状腺功能亢进指标、有效降低患者低钾发生率以及复发率,值得临床进一步推广应用。
Objective To compare the clinical efficacy of 131I and methimazole treatment of hyperthyroidism. Methods Total of 86 cases with hyperthyroidism admitted to the Fourth Affiliated Hospital of Guangxi Medical University from Jan. 2012 to Jan. 2013 were divided into observation group and control group according to random number table method,each with 43 cases. The observation group were treated with131 I,the control group received methimazole treatment,and the efficacy,hypokalemia incidence and recurrence rate of hyperthyroidism,and hyperthyroidism index( thyroid stimulating hormone（ TSH）,free tri-iodothyronine（ FT3）,free thyroxine（ FT4） of the two groups before and after treatment were compared.Results The total effective rate of the observation group was significantly higher than the control group[88. 4%（ 38 /43） vs 69. 8%（ 30 /43） ],the difference was statistically significant（ P < 0. 05）; the hypokalemia incidence of the observation group was significantly higher than the control group[25. 6%（ 11 /43） vs4. 6%（ 2 /43） ],and the recurrence rate was significantly lower than the control group[16. 3%（ 7 /43） vs51. 2%（ 22 /43） ],the differences were all statistically significant（ P < 0. 05）. Three months after treatment FT3,FT4 of both groups decreased,and at different time points the observation group lower than the control group; after three months of treatment TSH of both groups rose,and at each time point the observation group higher than the control group. Differences at different time points between the two groups were statistically significant（ P < 0. 05）. Conclusion The clinical efficacy of 131I treatment of hyperthyroidism is significant with high safety,which can significantly improve the hyperthyroidism index,effectively reduce the incidence of hypokalemia and recurrence rate,thus is worthy of further clinical application.
出处
《医学综述》
2016年第10期1967-1969,共3页
Medical Recapitulate
