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血清COMP和MMP-13在膝骨关节炎诊疗中的临床研究 被引量:4

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摘要 目的:研究膝骨关节炎患者血清中COMP、MMP-13水平与临床症状(VAS、WOMAC)的相关性,探讨COMP、MMP-13在膝骨关节炎诊断及疗效评价中的应用价值。方法:选取体检健康对照人群100例(对照组)。我科病房及门诊筛选明确诊断膝骨关节炎患者100例(治疗组),健康对照人群检测血清COMP,MMP-13水平;治疗组分别收集治疗前后WOMAC评分、VAS量表、血清COMP,MMP-13的水平,分析血清COMP,MMP-13的水平与临床症状的相关性。结果:治疗组患者血清中COMP,MMP-13水平明显高于对照组,有统计学差异(P<0.0001)。治疗组患者血清中COMP,MMP-13水平与膝骨关节炎患者临床症状(VAS、WOMAC评分)呈正相关(P<0.0001)。结论:血清中COMP,MMP-13水平与临床症状(VAS、WOMAC评分)呈正相关,测定KOA患者血清中COMP,MMP-13水平对进一步研究KOA早期发现并应用于临床疗效评价具有重要的意义。
出处 《影像研究与医学应用》 2017年第18期168-169,共2页 Journal of Imaging Research and Medical Applications
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