摘要
天然药物包括植物药、动物药和海洋药物,在我国天然植物药的使用有悠久的历史。但是随着现代科学技术的发展,马兜铃酸肾病的发现,人们逐渐对天然植物药的安全性产生了怀疑。此后多年,陆续从天然植物药中分离了多种有肝肾毒性的化合物。重点围绕已知的化合物代谢形成DNA加合物的过程阐述天然植物药致突变致癌分子机制的研究进展。
Natural medicines include botanicals, animal medicines and marine medicines. In China, there is a long history of the use of natural botanicals. However, with the development of modern science and technology, the discovery of aristolochic acid nephropathy, people have gradually doubted the safety of natural botanical drugs. Since then, many compounds with liver and kidney toxicity have been isolated from natural botanicals. This paper focuses on the research progress of molecular mechanisms of mutagenic carcinogenesis of natural botanicals by the process of known compound metabolism in the form of DNA adducts.
作者
夏彤
XIA Tong(Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China)
出处
《药物评价研究》
CAS
2019年第1期216-222,共7页
Drug Evaluation Research
