摘要
目的:比较磷酸铝凝胶、蒙脱石散剂对小儿红霉素静滴时胃肠道副反应的防治效果。方法:249例支原体肺炎患儿,随机分为磷酸铝凝胶治疗组、蒙脱石散剂治疗组和对照组各83例,观察三组在红霉素静滴时胃肠道副反应(包括腹痛、腹泻、恶心、呕吐)的发生情况。结果:磷酸铝凝胶和蒙脱石散剂治疗组红霉素静滴后胃肠道副反应发生率明显低于对照组(P<0.01),磷酸铝凝胶治疗组的发生率较蒙脱石散剂治疗组更低(P<0.05)。三组的治疗效果无明显差别(P>0.05)。结论:磷酸铝凝胶、蒙脱石散剂可明显减少红霉素静脉滴注时的胃肠道副反应而不影响其疗效,尤以磷酸铝凝胶的效果显著,可广泛用于临床实践。
AIM:To observe the preventive effects of aluminum phosphate gel and smectite powder on the side effects of erythromycin lactobionate via intervenous drop infusion for the gastrointestinal tract in children.METHODS:249 cases children with mycoplasmal pneumonia were randomly divided into three groups,aluminum phosphate gel group,smectite powder group and control group,83 cases in each group.The side effects of erythromycin lactobionate(abdominal pain,diarrhea,sicchasia,disgorging)for the gastrointestinal tract among three groups were observed.RESULTS:Compared with control group,the incidence rate of side effects was much lower in aluminum phosphate gel group and smectite powder group(P<0.01),which was lower in aluminum phosphate gel group than that in smectite powder group(P<0.05).There were no significant differences among the three groups(P>0.05).CONCLUSION:Aluminum phosphate gel and smectite powder significantly decrease the side effects of erythromycin lactobionate for the gastrointestinal tract in children,and especially the former,can be widely applied in pediatric clinic.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第12期1403-1405,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
磷酸铝凝胶
蒙脱石散剂
乳糖酸红霉素
胃肠道副反应
aluminum phosphate gel
smectite powder
erythromycin lactobionate
gastrointestinal tract side effect
