摘要
目的 观察丹参注射液早期治疗新生儿缺氧缺血性脑病 (HIE)的临床疗效及血清超氧化物歧化酶 (SOD)和丙二醛 (MDA)的变化。方法 将 6 0例HIE新生儿随机分为丹参治疗组与对照组各 30例 ,治疗组在常规治疗基础上加丹参注射液 2mL静滴 ,每日 1次 ,疗程 7d。两组均于治疗前及疗程结束后取股静脉血测定血清SOD活性及MDA浓度 ,同时做新生儿行为神经测定 (NBNA)评分及观察临床症状、体征的变化。结果 治疗组较对照组临床疗效、NBNA评分及SOD活性均显著提高 (P <0 .0 5 ) ,而血清MDA浓度显著下降 (P <0 .0 5 )。结论 丹参注射液可能通过提高SOD活性、清除氧自由基来减轻HIE患者的脑损害 ,提高疗效。
Objective It is to investigate the therapeutic effects of Danshen injection on neonate with hypoxic ischemic encephalopathy (HIE) and its influence on super oxide dismutase (SOD) and malondialdehyde (MDA) in early stage. Methods Sixty neonates with HIE were divided into two groups. The routine group were treated normally, while the Danshen group was treated with Danshen injection 2mL by intravenous drip, once a day for seven days additionally. Serum levels of SOD and MDA were measured from femoral vein in all cases before and after treatment. Neonatal behavioral and neurological assessment (NBNA) and clinical features were investigated concurrently. Results Compared with the routine group, the clinical effective rate, NBNA and the activity of SOD in Danshen group were significantly increased ( P <0.05). The concentration of MDA in Danshen group was obviously decreased than that in routine group ( P <0.05). Conclusion Danshen injection probably is relative to the cerebral damages and increase the clinical efficiency of HIE by reactivating SOD and destroying of oxyradical.
出处
《现代中西医结合杂志》
CAS
2003年第23期2511-2512,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
新生儿
缺氧缺血性脑病
丹参
neonate
hypoxic ischemic encephalopathy
Danshen
