摘要
目的 :比较双氯芬酸钠缓释胶囊和布洛芬缓释胶囊治疗类风湿性关节炎的疗效及安全性。方法 :采用随机分组的对照方法 ,将 168例患者分为治疗组 86例 ,口服双氯芬酸钠缓释胶囊 5 0mg ,bid ,对照组 82例 ,口服布洛芬缓释胶囊 3 0 0mg ,tid ,均以 2周为 1个疗程。结果 :两药均能显著改善类风湿性关节炎的症状 ,治疗组和对照组总有效率分别为 76.74% ,63 .41% (P >0 .0 5 ) ,显效率分别为 5 6.98% ,3 7.80 % (P <0 .0 5 )。不良反应均较轻。结论
Objective:To make a contrasted study of the curative effect and safety rate of diclofenac sodium sustained release capsules and ibuprofen sustained release capsules in the treatment of rheumatoid arthritis(RA). Methods:168 patients with RA were randomly divided into two groups. Patients of the treatment group( n =86) were given each 50 mg of diclofenac sodium in sustained release capsules, PO b.i.d., while those of the control group ( n =82) were given each 300 mg of ibuprofen in sustained release capsules, PO b.i.d.. The course of treatment in both groups lasted 2 weeks. Patients of both groups were subjected to 2 courses of treatment. Results:Both diclofenac sodium sustained release capsules and ibuprofen sustained release capsules were shown to dramatically ameliorate the symptoms of RA at the termination of the treatment. The overall effective rates were 76.74% and 63.41% in the treatment group and control group, respectively ( P >0.05). However, the rates of excellent therapeutic effect were 56.98% and 37.80% in the treatment group and control group, respectively( P <0.05). Conclusion:The curative effect and safety rate of diclofenac sodium sustained release capsules were found to be better than those of ibuprofen sustained release capsules.
出处
《医药导报》
CAS
2003年第12期860-861,共2页
Herald of Medicine
关键词
双氯芬酸钠
布洛芬
缓释胶囊
关节炎
类风湿性
Diclofenac sodium
Ibuprofen
Sustained release capsules
Rheumatoid arthritis
