摘要
目的 观察不同剂量卡维地洛对幼鼠在慢性心力衰竭发展中的左室重构作用。方法 采用腹主动脉缩窄术建立慢性心力衰竭 (CHF)模型 ,5周龄Wistar幼鼠随机分组为对照组、大剂量卡维地洛组、和中剂量卡维地洛组及小剂量卡维地洛组 ,另设假手术对照组。直接灌胃给药 ,每周测量体重 1次 ,给药 4周后行高频超声、血流动力学、心脏病理分析。结果 与假手术组比较 ,CHF组左室收缩末期内径LVESD(mm)、室间隔舒张末期厚度IVSTd(mm)、室间隔收缩末期厚度IVSTs(mm)、左室后壁舒张末期厚LVPWTd(mm)、左室后壁收缩末期厚度LVPWTs(mm)、左、右心室相对重量 (LVRW ,RVRW )、收缩压 (SBP)、舒张压(DBP)、平均压 (MBP)、左室收缩压 (LVSP)、左室舒张末压 (LVEDP)均显著升高 (P <0 .0 1 ) ,左室舒张末期内径LVEDD(mm)也明显升高 (P <0 .0 5 ) ;体重、左室短轴缩短率FS(% )、左室射血分数EF(% )、左室内压最大收缩率 (+dp/dtmax)、左室内压最大舒张率 (-dp/dtmax)均显著降低 (P <0 .0 1 )。与CHF组比较 ,卡维地洛组LVEDD、LVESDIVSTd、IVSTs、LVPWTd、LVPWTs、LVRW、RVRW、SBP、DBP、MBP、LVSP、LVEDP均呈剂量相关性下降 ,以大中剂量下降明显 (P <0 .0 5 ) ,体重、FS、EF、+dp/dtmax、-dp/dtmax均显著升高 (P <0 .0 1 )。结?
Objective To compare the effect of carvedilol in large,middle,or small dose in preventing left ventricular remodeling in chronic heart failure of juvenile rats.Method The animal model of chronic heart failure was established by constriction of abdominal aorta.The 36 surviving malerats of five weeks old were randomly divided into 4 groups:(1)CHF control( n =8);(2)large dose carvedilol (10mg·kg -1 ·d -1 , n =10);(3)middle dose carvedilol (1mg·kg -1 ·d -1 , n =10);(4)small dose carvedilol(0.1mg·kg -1 ·d -1 , n =8).Sham operated rats( n =8) were selected randomly as non infarction control.Carvedilol was administered bydirect gastric gavage.The weight of rats was observed every week.After 4 weeks of drug therapy,the highfrequency ultrasonography(HFUS),and the hemodynamic studies were performed,and the hearts of the juvenile rats were taken out in order for pathologic analysis.Results Compared with the sham operated group,LVESD,IVSTd,IVSTs,LVPWTd,LVPWTs,LVRW,RVRW,SBP,DBP,MBP,LVSP,LVEDP all sinificantly increased (all, P <0.01) in CHF group,as well as LVEDD( P < 0.05 ).A significant decrease could be seen in Weight,FS,+dp/dt max ,-dp/dt max .In comparsion with CHF groups,a dose dependent and significant decrease could be seen in LVEDD,LVESD,IVSTd,IVSTs,LVPWTd,LVPWTs,LVRW,RVRW,SBP,DBP,MBP,LVSP and LVEDP,especial large and middle dose carvedilol groups(all P <0.05～0.01).While a significant increase could be seen in Weight,EF,FS,+dp/dt max ,-dp/dt max .( P <0.01).Conclusion Carvedilol in no matter what dose effectively and dose dependently prevent LV remodeling in chronic heart failure of jurvenile rats and hemodynamics LV funnction,the weight of body in rats.
出处
《重庆医学》
CAS
CSCD
2003年第12期1686-1688,1691,共4页
Chongqing medicine
关键词
卡维地洛
慢性心力衰竭
左室重构
幼鼠
caevedilol
chronic heart failure
left ventricular remodeling
juvenile rat
