摘要
目的:前瞻性评价国产α-2b 干扰素治疗 CHB 的疗效.方法:32例 CHB 患者,每次α-2b 干扰素6MU、皮下注射、3次/wk,疗程为3mo,停药后随访6mo.16例患者于治疗前后进行了肝活检. 结果:治疗结束时,完全应答1例(3.1%),部分应答12例(37.5%),无应答19例(59.4%),总应答率为40.6%(13/32).随访结束时,总应答率为50.0%(16/32).结论:α-干扰素具有后续抗 HBV 作用.部分抗病毒无效的患者仍可从α-干扰素的治疗中获益.
AIM:To prospectively evaluate the response to interferon α-2b(IFN)in chronic hepatitis B. METHODS:We enrolled a total number of 32 patients with CHB for the study.The patients received 6 million units of IFNα-2b subcutaneously thrice a weak for 3 months and also a follow-up for 6 months.Liver biopsies were obtained in 16 patients with CHB before and after treatment. RESULTS:The complete response rate,partial response rate and non-response rate were 3.1%,37.5% and 59.4%, respectively.The overall response rate was 40.6%(13/32) at the end of treatment.The overall response rate was 50.0%(16/32)at the end of follow-up. CONCLUSION:Interferon-α had lasting antiviral effects in chronic hepatitis B.Some of the patients non-responsive to antiviral therapy acquired benefits from interferon-α treatment.
出处
《世界华人消化杂志》
CAS
2003年第11期1723-1726,共4页
World Chinese Journal of Digestology
