摘要
目的 探讨喘可治注射液雾化吸入治疗支气管哮喘 (简称哮喘 )可能的作用机制。方法 复制大鼠哮喘模型 ,以必可酮气雾剂和地塞米松雾化吸入作为对照 ,采用双抗体夹心ELISA法测定各组大鼠肺组织匀浆中白介素 (IL) 4和γ干扰素 (IFN γ)的含量。结果 喘可治大、中剂量组能明显升高IFN γ/IL 4比值 ,与必可酮对照组相比 ,差异无显著性 (P >0 .0 5 ) ,但优于地塞米松对照组 (P <0 .0 5 )。结论 喘可治大、中剂量雾化吸入能通过影响IFN γ和IL 4的含量来调节Th1/Th2细胞比例 ,纠正免疫失衡 。
Objective To investigate the possible mechanism of nebulizing Chuankezhi in treatment of asthma. Methods Replicated the rat asthma model and used nebulizing becotide recotide and dexamethazone (as controls); and then detected the contents of IL 4 and IFN γ in the lung tissue from the asthmatic rats by ELISA. Results In the group using large and moderate dosages of nebulizing Chuankezhi, IFN γ/IL 4 ratio was found significantly increased ( P <0.01). Compared with the becotide group, there was no significant statistical significance, but the efficacy was superior to the dexamethazone group ( P >0.05). Conclusion Large and moderate dosages of nebulizing Chuankezhi can influence IFN γ and IL 4 contents, and modulate the ratio of Th1/ Th2 cells so as to correct the immuno imbalance resulting in improvement of the asthmatic attack.
出处
《上海医学》
CAS
CSCD
北大核心
2003年第12期904-906,共3页
Shanghai Medical Journal
关键词
喘可治注射液
雾化吸入
支气管哮喘
大鼠
免疫失衡
实验
地塞米松
Chuankezhi injection
Nebulizing therap
Interleukin 4
Interferon γ
Enzyme linked immunosorbent assay
