摘要
目的 :探讨了 2型糖尿病肾病患者血管内皮生长因子的水平。方法 :应用酶联双抗体夹心法测定了 31例无糖尿病肾病和 5 5例糖尿病肾病患者血管内皮生长因子含量 ,并与 35名正常健康人作对照。结果 :2型糖尿病无肾病组和有肾病组血管内皮生长因子水平均高于正常人组 ,尤以糖尿病肾病为甚 (p <0 0 1 ) ,糖尿病肾病组与无糖尿病肾病组比较 ,差异也有显著性 (p <0 0 1 )。 结论 :2型糖尿病肾病的发生与发展与血管内皮生长因子水平密切相关。
Objective To investigate the plasma VEGF levels in patients with typeⅡ diabetes. Methods Plasma VEGF levels were measured with EIA in 55 cases of diabetic nephrosis, 31 cases of diabetes without nephrosis and 35 controls. Results The plasma levels of VEGF in diabetic patients with as well as without hephrosis were both significantly higher than those in controls ( p <0 01, p <0 005). In diabetic patients with hephrosis, plasma levels of VEGF were significantly higher than those in patients without hephrosis ( p <0 01). Conclusion Development of nephrosis in patients with typeⅡ diabetes is correlated to the higher concentrations of VEGF.
出处
《放射免疫学杂志》
CAS
2003年第6期379-380,共2页
Journal of Radioimmanology
