摘要
目的分析肾功能不全对急性冠脉综合征患者血浆N端脑钠肽前体水平的影响。方法选择120例肾功能不全的急性冠脉综合征患者为A组,80例急性冠脉综合征患者(肾功能正常)为B组,70例非冠心病患者(肾功能正常)为C组,比较三组患者的一般资料、血浆N端脑钠肽前体水平、肾小球滤过率及血肌酐情况。结果 A组患者的血浆N端脑钠肽前体水平为(5.21±0.16)nPg/ml,显著高于B组患者(4.72±0.14)nPg/ml(P<0.05),A组、B组血浆N端脑钠肽前体水平均显著高于C组患者(4.19±0.11)LnPg/ml(P<0.05)。A组患者血肌酐值为(85.16±2.31)μmol/L,显著高于B、C两组患者(73.12±1.71,74.12±2.11)μmol/L(P<0.05)。A组患者的肾小球滤过率为(70.13±1.41)ml/(min1.73 m^2),显著低于B、C两组患者(80.15±2.11,84.12±2.81 ml/min 1.73 m^2)(P<0.05)。结论肾功能不全显著升高了急性冠脉综合征患者血浆N端脑钠肽前体水平,同时受损的肾功能降低了肾小球滤过率,直接影响血浆N端脑钠肽前体的清除,导致了血浆浓度升高。因此,血浆N端脑钠肽前水平对于提示急性冠脉综合征合并肾功能不全患者的预后具有高度敏感性。
Objective Analysis of the influence of renal insufficiency on level of N-pro brain natriuretic peptide in patients with acute coronary syndrome.Methods Select 120 cases of renal insufficiency and with acute coronary syndrome patients in group A,80 cases of only acute coronary syndrome patients in group B,70 cases of non-coronary heart disease patients in group C.Comparison of the three groups of patients with general information,N-pro brain natriuretic peptide and GFR^CRE.Results There are significant difference of three groups with N-pro brain natriuretic peptide and GFR^CRE.Conclusion Renal insufficiency influence the level of N-pro brain natriuretic peptide in patients with acute coronary syndrome.
出处
《中华心脏与心律电子杂志》
2015年第4期20-22,共3页
Chinese Journal of Heart and Heart Rhythm(Electronic Edition)
