摘要
目的观察锌剂三联疗法治疗幽门螺杆菌(Hp)相关性十二指肠溃疡疗效。方法87例患者随机分为两组。锌剂组(45例):醋氨己酸锌300mg熏2次/d熏法莫替丁20mg熏2次/d熏阿莫西林500mg熏2次/d鸦铋剂组(42例):得诺240mg熏2次/d熏法莫替丁20mg熏2次/d熏阿莫西林500mg熏2次/d。疗程均为4周。疗程结束1周后胃镜检查。结果锌剂组的Hp根除率和溃疡愈合率分别为86.87%和91.11%,铋剂组分别为88.10%和90.48%,两者比较无显著性差异(P>0.05),但平均不良反应积分铋剂组为4.36,锌剂组为2.37,两者比较有显著性差异(P<0.05)。结论两种疗法治疗Hp相关性十二指肠溃疡疗效相当,但是铋剂组不良反应发生率较高。
Objective To compare different triple therapy for treatmeat of Helicobacter pylori(Hp)associated duodenal ulcer(DU).Methods The87patients were randomly divided into two groups.Treatment group(45patients)was given zinc acexamate300mg,2/d,and famotidine20mg,2/d,and amoxicillin500mg,2/d;control group(42patients)was given De-Nol240mg,2/d,and famotidine20mg,2/d,and amoxicillin500mg,2/d.The treatment course was four weeks.Upper endoscopy was performed one month after the end of course.Results Eradication rate of Hp and the healing rates of DU in treatment group were86.67%and91.11%,while88.10%and90.48%in control group,but discrepancy was not significant at statistics(P>0.05).The mean total adverse drug reaction(ADR)scorce was4.36in control group,2.37in treatment group;the former was higher than the latter(P<0.05).Conclusion Both regimens are effective in treatment of HP-associated DU,but at the same time ADRs occur more often in control group(P<0.05).
出处
《实用医药杂志》
2003年第12期889-890,共2页
Practical Journal of Medicine & Pharmacy
