摘要
目的探讨血栓弹力图(TEG)在冠状动脉介入术患者抗血小板效果、心脏不良事件评估中的应用。方法回顾性分析,将2014年8月～2016年8月在我院接受冠状动脉介入术治疗的60例患者作为研究对象,随机分组,对照组30例,给予单纯冠状动脉介入抗血小板治疗;干预组30例,在抗血小板治疗中给予血栓弹力图监测血凝状况,对手术治疗2个月后两组P、K、α角、血小板抑制率以及心脏不良事件发生情况进行评估。结果干预组与对照组患者治疗后的TEG参数呈现出明显差异(P<0.05);干预组治疗后的ARA途径、ADP途径血小板抑制率与对照组呈现明显差异(P<0.05);且干预组抗血小板治疗后心脏不良事件发生频率为2例,占6.7%,显著低于对照组的26.7%(P<0.05)。结论对冠状动脉介入术抗血小板治疗中给予TEG监测,能够有效地了解患者的血凝状况,从而调整治疗方案、增强对血小板的抑制效率,降低心脏不良事件发生率。
Objective To explore the application of thrombus stretch(TEG)in the evaluation of antiplatelet effect and adverse cardiac events in patients with coronary artery intervention.Methods Retrospective analysis was conducted.Sixty patients with coronary intervention were treated from August 2014 to August 2016 in our hospital.Randomized group and control group(n=30)received coronary artery interventional antiplatelet 30 patients in the intervention group were treated with thrombus elasticity in the antiplatelet therapy to monitor the hemagglutination status,and the incidence of P,K,α,platelet inhibition and cardiac adverse events were evaluated after two months of operation.Results The TEG parameters of the intervention group and the control group showed significant difference(P<0.05);the intervention group after treatment ARA pathway,ADP pathway platelet inhibition rate and the control group showed significant difference(P<0.05).The frequency of adverse events in the intervention group was 6.7%,which was significantly lower than that in the control group(P<0.05).Conclusion The monitoring of TEG in antiplatelet therapy of coronary intervention can effectively understand the blood coagulation status of patients,so as to adjust the treatment plan,enhance the inhibition efficiency of platelets,and reduce the incidence of adverse cardiac events.
作者
林桂花
杨晓冬
LIN-Gui-hua;YANG Xiao-dong(Department of Hematology,Ningde Hospital,affiliated to Fujian Medical University,Ningde,352100,China)
出处
《血栓与止血学》
2019年第2期199-201,204,共4页
Chinese Journal of Thrombosis and Hemostasis
