摘要
目的观察老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者低氧诱导因子-1(HIF-1)和脑红蛋白(Ngb)水平变化,分析其在老年OSAHS患者执行功能障碍评估中的意义。方法以2013年12月至2014年12月唐山市丰润区人民医院确诊的OSAHS患者121例为观察对象,选取121例同期健康体检的非OSAHS人群为对照组。采用执行缺陷综合征的行为评价标准(BADs)评测执行功能;采用酶联免疫吸附测定法(ELISA)测定血清HIF-1及Ngb水平。结果 OSAHS组BADs各项评分低于对照组,而血清HIF-1和Ngb水平高于对照组(P<0.05);OSAHS组血清HIF-1和Ngb水平与睡眠呼吸暂停低通气指数(AHI)和微觉醒指数(M-AI)呈正相关,与LSa O2和MSa O2呈负相关(P均<0.01);血清HIF-1和Ngb水平分别与BADs总分呈负相关(P均<0.05);血清HIF-1水平预测OSAHS患者执行功能障碍的ROC曲线下面积为0.815(P<0.05),灵敏度为0.837,特异度为0.888;Ngb水平预测OSAHS患者执行功能障碍的ROC曲线下面积为0.785(P<0.05),灵敏度为0.898,特异度为0.606。结论 OSAHS患者血清HIF-1和Ngb水平可用于评估执行功能障碍。
Objective To investigate the changes of the level of Hypoxia-Inducible Factor-1（ HIF-1） and Neuroglobin（ Ngb） in the elderly patient with obstructive sleep apnea hypopnea syndrome（ OSAHS） and to analyze the significance of the evaluation for executive dysfunction evaluation. Methods 121 quinquagenarian patients with OSAHS from 2013,12 to 2014,12 were chosen as observed objects and 121 quinquagenarian non-OSAHS cases during the same period were collected as control group. The executive dysfunction was evaluated with Behavioral Assessment of Dysexecutive syndrome（ BADs） evaluation for executive dysfunction while the levels of serum HIF-1and Ngb were determined by enzyme-linked immunosorbent（ ELISA） method. Results Compared with the non-OSAHS patients,the scores of BADs in OSAHS group were lower significantly while the levels of serum HIF-1 and Ngb were higher significantly（ P < 0. 05）. HIF-1 or Ngb levels was respectively significantly positively correlated with Apnea Hypopnea Index and Micro-arousal Index while respectively significantly negatively correlated with LSaO2 and MSaO2（ P < 0. 05）.HIF-1 or Ngb levels was respectively significantly negatively correlated with BADs scores（ P < 0. 05）. ROC curve showed that the area of HIF-1 under the ROC curve for evaluating execution dysfunction was 0. 815 and sensitivity and specificity respectively were 0. 837 and 0. 888（ P < 0. 05） while the area of Ngb under the ROC curve for evaluating execution dysfunction was 0. 785 and sensitivity and specificity respectively were 0. 898 and 0. 606（ P < 0. 05）. Conclusion The changes of HIF-1 and Ngb level can evaluate executive dysfunction of OSAHS patients,and HIF-1 level was superior to the Ngb level for the early evaluation executive dysfunction in patients with OSAHS.
出处
《宁夏医科大学学报》
2016年第7期746-749,754,共5页
Journal of Ningxia Medical University
基金
河北省医学科学研究重点课题(ZD20140500)
