摘要
目的 :探讨表皮生长因子受体与胰岛素样生长因子受体在子宫肌瘤发病机理中的作用。方法 :应用流式细胞术定量分析法及免疫组化S -P法分析比较 4 0例子宫肌瘤患者子宫肌层和子宫肌瘤组织表皮生长因子受体 (EGFR)和胰岛素样生长因子受体 (IGF - 1R)的含量及表达水平 ,月经周期根据月经史及子宫内膜组织来判断。结果 :子宫肌瘤组织EGFR ,IGF - 1R的表达及含量显著高于同一子宫邻近正常肌层组织 (p <0 0 5 ,p <0 0 1 ) ;子宫肌瘤组织与其邻近肌层组织相比较 ,EGFR的含量及表达在分泌期无显著性差异 (p >0 0 5 ) ,而在增生期含量明显增高 (p <0 0 5 ) ;而IGF - 1R的表达与月经周期无关。 结论 :EGFR ,IGF - 1R在子宫肌瘤组织中高表达与其发生。
Objective To study the role of EGFR and IGF-1R in the pathogenesis of uterine leiomyoma. Methods EGFR and IGF-1R contents and expression levels of leiomyoma tissue and adjacent normal myometrium in 40 surgical specimens were detected with quantitative flow cytometry and immunohistochemical SP localization methed respectively. The menstrual phase of the specimen was dictated by the histology of the endometrium. Results The contents and expression levels of EGFR and IGF-1R were significantly bigher in the myoma tissue than those in the hormal myometrium ( p <0 01, p<0 01 ). Furthar analysis showed that the EGFR contents and experssion in the myoma tissue were significantly higher than those in adjacent myometrium during the proliferative phase only ( p <0 05) but not 80 during the secretory phase, For IGF-1R, the contents and expression were significantly higher during both phases. Conclusion The higher content and expression of EGFR and IGF-1R in the myoma tissue might regulate the growth of the tumor.
出处
《放射免疫学杂志》
CAS
2003年第6期326-327,共2页
Journal of Radioimmanology
