摘要
cGAS-STING信号通路是细胞内一条重要的免疫应答通路,通过调节起始免疫和适应性免疫在病原体感染和肿瘤中发挥重要调控作用,并与多种人类自免疫疾病相关。全文就cGAS-STING信号通路的调控、与肿瘤相关性和免疫治疗等方面进行阐述,旨在为靶向该通路的免疫治疗提供理论基础。
cGAS-STING signaling pathway is one of the most significant immune response pathway in cells.Through the regulation of innate immunity and adaptive immunity,it plays an important role in pathogen infection,tumors,as well as several human autoimmune diseases.This article reviews the function,regulation of the cGAS-STING signal pathway,its correlation with tumor and application in immunity therapy,which may provide the information for anticancer therapy.
作者
马肖静
周慧婷
董熠
李营歌
郑忠亮
姚颐
MA Xiao-jing;ZHOU Hui-ting;DONG Yi;LI Ying-ge;ZHENG Zhong-liang;YAO Yi(College of Life Sciences,Wuhan University,Wuhan430071,China;People’s hospital of Wuhan University,Wuhan430060,China)
出处
《肿瘤学杂志》
CAS
2019年第7期654-657,共4页
Journal of Chinese Oncology
