摘要
平足蛋白(podoplanin,PDPN)作为淋巴内皮细胞的标志,在炎症的发生发展、淋巴管的分化形成及血小板的聚集等方面都起着一定作用。近来研究发现在肿瘤组织或肿瘤微环境中也有不同水平的PDPN表达,可作为评估肿瘤患者预后的生物学指标。进一步研究还发现PDPN及其相关信号通路可影响癌细胞的侵袭转移,进而促进肿瘤的发生发展。全文对PDPN研究现状进行综述。
Podoplanin(PDPN)as marker of lymphatic endothelial cells is involved in the onset and development of inflammation,differentiation of lymph vessels and platelet aggregation.In recent years,researchers have demonstrated that PDPN is overexpressed on the surface of tumor cells and tumor microenvironment,it can affect the biological behavior of tumor cells,promoting tumor progression,invasion and metastasis,and it may be used as a biological marker of tumor prognosis.This article reviews the current research progress of PDPN and its roles in tumor progression.
作者
董熠
李营歌
姚颐
宋启斌
DONG Yi;LI Ying-ge;YAO Yi;SONG Qi-bin(Cancer Center,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《肿瘤学杂志》
CAS
2019年第4期345-348,共4页
Journal of Chinese Oncology
基金
国家自然科学基金(81670123)
关键词
平足蛋白
肿瘤
机制
,podoplanin
tumor
mechanism
