摘要
目的:分析吗替麦考酚酯(MMF)诱导治疗弥漫增生性狼疮性肾炎的效果。方法:随机选取50例弥漫增生性狼疮性肾炎(Ⅳ型LN)且伴新月体(≥15%)形成的患者,随机分成治疗组和对照组,每组各25例。治疗组采取激素联合MMF诱导治疗,对照组采取IV-CTX冲击治疗。回顾性比较两组治疗6个月的缓解率。结果:治疗组总缓解率明显高于对照组(P<0.05)。治疗组补体C3恢复正常率显著优于对照组(P<0.05)。结论:MMF诱导治疗弥漫增生性狼疮性肾炎的效果显著。
Objective:To analyze the effect of mycophenolate mofetil inductive treatment in diffuse proliferative lupus nephritis.Methods:50 patients with diffuse proliferative lupus nephritis(Ⅳ type LN) and crescent(≥15%) formation were randomly selected.They were randomly divided into the treatment group and the control group with 25 cases in each.The treatment group was given hormone combined with MMF inductive treatment.The control group was given IV-CTX impact treatment.The remission rates of two groups after 6 months treatment were retrospectively compared.Results:The total remission rate of the treatment group was significantly higher than that of the control group(P<0.05).The complement C3 recovery normal rate of the treatment group was significantly better than that of the control group(P<0.05).Conclusion:The effect of mycophenolate mofetil inductive treatment in diffuse proliferative lupus nephritis is significant.
出处
《中国社区医师》
2015年第32期40-40,42,共2页
Chinese Community Doctors
关键词
狼疮性肾炎
新月体
吗替麦考酚酯
环磷酞胺
诱导治疗
Lupus nephritis
Crescent
Mycophenolate mofetil
Cydophosphamide
Inductive treatment
