摘要
目的:分析老年肿瘤患者化疗后肝损伤的临床特点。方法:2012年9月-2014年1月收治化疗后肝损伤老年肿瘤患者90例,对临床特点进行回顾性分析。结果:90例患者化疗过程中出现肝损伤42例(46.7%),其中合并慢性病毒性肝炎3例(7.1%),与未发生肝损伤患者比较,差异无统计学意义(P>0.05);肝脏转移20例(47.6%),差异具有统计学意义(P<0.05);对比两组患者的肿瘤类型差异显著,但和肿瘤分期无明显关联。肝损伤主要表现是丙氨酸氨基转移酶上升;前两个化疗周期是肝损伤发生的主要时期,化疗显效率达95.2%。结论:老年肿瘤患者化疗后肝损伤与其年龄、肿瘤分期以及合并慢性病毒性肝炎之间无明显关联性,肝脏转移是导致肝损伤的重要因素之一,化疗引起的肝损伤预后效果较好,无需进行减量或延迟化疗。
Objective:To investigate the clinical characteristics of liver damage in aged cancer patients after chemotherapy.90 cases with liver injury in aged cancer patients after chemotherapy were selected from September 2012 to January 2014.The clinical features were retrospectively analyzed.Results:42 cases of liver injury occured in 90 patients during chemotherapy(46.7%), while 3 cases combined with chronic viral hepatitis(7.1%),there was no significant difference with patients without liver injury(P>0.05).Liver metastasis in 20 cases(47.6%),with significant difference(P<0.05).The comparison between the two groups of patients with tumor type was significantly difference,but no significant correlation with tumor staging.The main features of liver injury was that the increased alanine aminotransferase.The first two cycles of chemotherapy is the major period of liver injury,the markedly rate of chemotherapy was 95.2%.Conclusion:There was no significant correlation among aged cancer patients with liver injury after chemotherapy and their age,tumor stage,chronic viral hepatitis,liver metastasis is one of the important factors leading to liver injury,the prognosis of liver damage by chemotherapy effect is good and is not require reduction or delayed chemotherapy.
出处
《中国社区医师》
2015年第10期39-39,41,共2页
Chinese Community Doctors
关键词
化疗
老年肿瘤
肝损伤
Chemotherapy
Aged cancer
Liver injury
