摘要
目的:研究BNP(BNP)对急性ST段抬高型心肌梗死(STEMI)患者的临床应用价值及与预后相关合并症的关系。方法:检测入选患者入院时[即发病后(10.6±8.8)h]及入院后2周血浆BNP水平,并随访30 d、3个月及6个月病死率及主要心脏不良事件(MACE)(心源性死亡、心肌梗死或缺血导致的靶病变、血运重建等临床事件)发生率。结果:随着BNP水平的增高,各组死亡率及MACE发生率显著增高。Logistic多元回归分析显示,BNP是心血管事件的独立危险因素(OR=1.23,95%的可信区间0.988-1.531,P<0.05)。结论:血浆BNP在预测STEMI并发症中有重要作用,或许是评价心肌梗死并发症和后期病死率一个重要的无创检测方法。
Objective:To study the clinical value of BNP(B-type natriuretic peptide,BNP) in patients with acute ST segment elevation myocardial infarction(STEMI) patients and its relationship with prognosis complications.Methods:Detection of the level of plasma BNP at admission[after(10.6±8.8) hours of the onset] and 2 weeks after admission,and followed up the patients,to observed the mortality and incidence of major adverse cardiac events(cardiac death,myocardial infarction or target lesion caused by ischemia,revascularization and other clinical events) in 30 days,3 month and 6 month.Results:With the increase of BNP level,the mortality and the rate of MACE significantly increased.Multivariate logistic regression analysis showed that BNP was an independent risk factor for cardiovascular events(OR=1.23,95% confidence interval was 0.988-1.531,P<0.05).Conclusion:Plasma BNP can play an important role in the prediction of complications of STEMI.It may be an important non-invasive detection evaluation methods in myocardial infarction complication and the mortality.
关键词
BNP
急性ST段抬高型心肌梗死
临床意义
BNP
ST segment elevation acute myocardial infarction
Clinical significance
