摘要
AGO(argonaute)蛋白家族存在于几乎所有的物种中,是一种高度保守的碱性蛋白。AGO蛋白在细胞整个生命进程中发挥重要角色,参与m RNA降解、基因沉默、蛋白翻译等多种细胞进程。AGO蛋白也可与不同的非编码RNA结合发挥重要的作用。研究非编码RNA基因的作用机制,有助于发现新的与器官形成、胚胎发育和生长相关的调控因子,进一步探究人类疾病发病机制,为开发新的治疗各种疾病的手段提供理论基础。该文主要对AGO在非编码RNA中的生物学作用加以综述。
The argonaute(AGO)protein family is found in almost all species and is a highly conserved basic protein.AGO protein plays an important role in the whole life process of cells,and participates in various cellular processes such as mRNA degradation,gene silencing,and protein translation.Understanding the mechanism of noncoding RNA genes is helpful to discover new regulators of organogenesis,embryonic development and growth,to understand the pathogenesis of human diseases,and to provide theoretical basis for the development of new treatments for various diseases.This review focuses on the biological role of AGO in non-coding RNA.
作者
张美玲
陈思佳
钟照华
Zhang Meiling;Chen Sijia;Zhong Zhaohua(Department of Microbiology,Harbin Medical University,Harbin 150081,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第6期1144-1149,共6页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81871652、81571999)资助的课题~~
关键词
AGO
非编码RNA
基因沉默
转录
翻译
AGO
non-coding RNA
gene silencing
transcription
translation
